نتایج جستجو برای: hspb1
تعداد نتایج: 443 فیلتر نتایج به سال:
Distal hereditary motor neuropathies (dHMN) are a group of rare hereditary neuromuscular disorders characterized by an atrophy that affects peroneal muscles in the absence of sensory symptoms. To date, 23 genes are thought to be responsible for dHMN, four of which encode chaperones: DNAJB2, which encodes a member of the HSP40/DNAJ co-chaperone family; and HSPB1, HSPB3, and HSPB8, encoding three...
HSPB5 (also called αB-crystallin) is a ubiquitously expressed small heat shock protein. Mutations in HSPB5 have been found to cause cataract, but are also associated with a subgroup of myofibrillar myopathies. Cells expressing each of these HSPB5 mutants are characterized by the appearance of protein aggregates of primarily the mutant HSPB5. Like several members of the HSPB family, HSPB5 can fo...
Age-related hearing loss - presbycusis - is the number one neurodegenerative disorder and top communication deficit of our aged population. Like many aging disorders of the nervous system, damage from free radicals linked to production of reactive oxygen and/or nitrogen species (ROS and RNS, respectively) may play key roles in disease progression. The efficacy of the antioxidant systems, e.g., ...
پژوهش حاضر بر غربالگری بر پایه hspb1 هشت جمعیت گربه دنیا به منظور بررسی ارتباط جایگاه به تازگی یافت شده در موارد تومور پستانی گربه تاکید دارد. تعداد کل 180 گربه بر اساس جایگاه حذف hspb1 4 bp (1514-1517del4) که در 6 مورد تومور پستانی در نژاد گربه سیامی دیده شد، غربال شدند. مطالعه ارتباط مورد-شاهدی غیر معنی داری با p=0.201 را تایید کرد و به طور کلی فراوانی 30/0 آلل جهش یافته در محدوده 20/0 تا40/0...
Research background. Ficus deltoidea (mistletoe fig) is a shrub well known among locals in Malaysia primarily for its treatment of toothaches, colds and wounds. The aim this study to determine the potential leaves, sourced from three different varieties F. deltoidea, exhibit antioxidant activity, reduction lipid concentration, protein expression steatosis-induced liver cell lines. Experimental ...
BACKGROUND An arg120gly (R120G) missense mutation in HSPB5 (alpha-beta-crystallin ), which belongs to the small heat shock protein (HSP) family, causes desmin-related cardiomyopathy (DRM), a muscle disease that is characterized by the formation of inclusion bodies, which can contain pre-amyloid oligomer intermediates (amyloid oligomer). While we have shown that small HSPs can directly interrupt...
The Charcot-Marie-Tooth disease 2F (CMT2F) and distal hereditary motor neuropathy 2B (dHMN2B) are caused by autosomal dominantly inherited mutations of the heat shock 27 kDa protein 1 (HSPB1) gene and there are no specific therapies available yet. Here, we assessed the potential therapeutic effect of HDAC6 inhibitors on peripheral neuropathy with HSPB1 mutation using in vitro model of motor neu...
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