نتایج جستجو برای: hsp90 beta

تعداد نتایج: 192746  

Journal: :The Journal of biological chemistry 2002
Mehul Shah Kirit Patel Victor A Fried Pravin B Sehgal

Interleukin-6 (IL-6) initiates STAT3 signaling in plasma membrane rafts with the subsequent transit of Tyr-phosphorylated STAT3 (PY-STAT3) through the cytoplasmic compartment to the nucleus in association with accessory proteins. We initially identified caveolin-1 (cav-1) as a candidate STAT3-associated accessory protein due to its co-localization with STAT3 and PY-STAT3 in flotation raft fract...

2017
Ran Jing Cameron B. Duncan Stephen A. Duncan

We have previously shown that the transcription factor HNF4A is required for the formation of hepatic progenitor cells from endoderm that has been derived from human induced pluripotent stem cells. We reasoned that we could uncover regulatory pathways with novel roles in hepatocyte differentiation by identifying cellular processes that regulate HNF4A. We, therefore, performed a screen of 1120 s...

ژورنال: :مجله دانشکده پزشکی اصفهان 0
فرزاد کتیرائی استادیار، گروه پاتوبیولوژی، دانشکده ی دامپزشکی، دانشگاه تبریز، تبریز، ایران اسماعیل بابایی استادیار، گروه بیولوژی، دانشکده ی علوم طبیعی، دانشگاه تبریز، تبریز، ایران عادل قادری دامپزشک، گروه پاتوبیولوژی، دانشکده ی دامپزشکی، دانشگاه تبریز، تبریز، ایران جواد اشرفی هلان استاد، گروه پاتوبیولوژی، دانشکده ی دامپزشکی، دانشگاه تبریز، تبریز، ایران

چکیده مقدمه:   ژن های camca1 و hsp90 در ایجاد مرگ سلولی برنامه ریزی شده در سلول های قارچی نقش دارند. هدف از انجام این مطالعه، بررسی اثرات ضد قارچی نانوکورکومین دندروزومی علیه گونه های candida و بررسی اثر این دارو بر بیان این ژن ها بود. روش ها: حساسیت چهار گونه ی candida به کورکومین و نانوکورکومین طبق روش clsim27-s4 مورد بررسی قرار گرفت. در ادامه، بیان ژن های hsp90 و camca1 در سلول های تیمار شده...

Journal: :British journal of pharmacology 2002
Mariarosaria Bucci Fiorentina Roviezzo Carla Cicala Aldo Pinto Giuseppe Cirino

1. The L-arginine-NO pathway has been implicated in the vasorelaxant effect of 17-beta-oestradiol. Here we have addressed the involvement of two distinct activation steps of endothelial nitric oxide synthase (eNOS) in the 17-beta-oestradiol-induced vasorelaxant effect on rat aortic rings. 2. Rat aortic rings contracted with phenylephrine (PE) 1 microM relaxed in a concentration related fashion ...

2015
Juan Zhang Kehong Tan Xing Meng Wenwen Yang Haiyan Wei Rongli Sun Lihong Yin Yuepu Pu Paul B. Tchounwou

The small peptides representation of the original proteins are a valuable source of information that can be used as biomarkers involved in toxicity mechanism for chemical exposure. The aim of this study is to investigate serum peptide biomarkers of benzene exposure. C57BL/6 mice were enrolled into control group and benzene groups of 150 and 300 mg/kg/d Serum peptides were identified by mass spe...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Kusumam Joseph Baby G Tholanikunnel Allen P Kaplan

Bradykinin is a major mediator of swelling in C1 inhibitor deficiency as well as the angioedema seen with ACE inhibitors and may contribute to bronchial hyperreactivity in asthma. Formation of bradykinin occurs in the fluid phase and along cell surfaces requiring interaction of factor XII, prekallikrein, and high M(r) kininogen (HK). Recent data suggest that activation of the kinin-forming casc...

Journal: :The Journal of biological chemistry 2006
Christopher G Evans Susanne Wisén Jason E Gestwicki

Alzheimer disease is a neurological disorder that is characterized by the presence of fibrils and oligomers composed of the amyloid beta (Abeta) peptide. In models of Alzheimer disease, overexpression of molecular chaperones, specifically heat shock protein 70 (Hsp70), suppresses phenotypes related to Abeta aggregation. These observations led to the hypothesis that chaperones might interact wit...

Journal: :Molecular & cellular proteomics : MCP 2010
Anuradha Radhakrishnan Dawn Yeo Gaie Brown Myint Zu Myaing Laxmi Ravi Iyer Roland Fleck Boon-Huan Tan Jim Aitken Duangmanee Sanmun Kai Tang Andy Yarwood Jacob Brink Richard J Sugrue

In this study, we used imaging and proteomics to identify the presence of virus-associated cellular proteins that may play a role in respiratory syncytial virus (RSV) maturation. Fluorescence microscopy of virus-infected cells revealed the presence of virus-induced cytoplasmic inclusion bodies and mature virus particles, the latter appearing as virus filaments. In situ electron tomography sugge...

Journal: :Bioorganic & medicinal chemistry letters 2008
Susanne Wisén John Androsavich Christopher G Evans Lyra Chang Jason E Gestwicki

Molecular chaperones, such as Hsp70 and Hsp90, are responsible for a variety of protective, anti-apoptotic functions. While inhibitors of Hsp90, such as geldanamycin and its derivative 17-AAG, are well known and important anti-cancer leads, Hsp70 has received less attention. Interesting lead candidates for Hsp70 share a dihydropyrimidine core; however, the preferred display of pendant functiona...

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