OBJECTIVE To analyze the biomechanical and tomographic effects of hormone replacement therapy (HRT) on femurs from rats subjected to induced menopause. METHODS Forty-five adult Wistar rats were divided equally into three groups. The first and second groups consisted of rats subjected to oophorectomy, and the third was the control group, consisting of nonoophorectomized rates. After verifying ...

Exercise elevates growth hormone (GH) and prolactin (PRL) blood concentrations in premenopausal women. Postmenopausal women taking hormone replacement therapy (HRT) maintain higher estrogen levels that could affect GH and PRL. The purpose of the study was to determine the effects of HRT on GH and PRL responses to treadmill exercise. Seventeen healthy women who were postmenopausal (naturally or ...

Hormone replacement therapy (HRT) is associated with reduced risk of coronary heart disease (CHD) and stroke in observational studies; however the possibility of confounding by other risk factors requires prospective assessment of its risks and benefits in randomised controlled trials. The HERS trial of oral HRT in secondary CHD prevention observed an early increased risk of myocardial infarcti...

Hormone replacement therapy (HRT) may reduce lung cancer risk. Dietary boron may have actions similar to those of HRT; however, no previous study has reported the associations between dietary boron intake and lung cancer risk or the joint effects of boron intake and HRT use on lung cancer risk. The authors examined the associations between boron intake and the joint effects of boron intake and ...

The aim of this study was to characterise new users of hormonal replacement therapy (HRT) for the relief of menopausal symptoms and to compare these women with never-users of HRT; 402 new users and 804 never-users were studied. Hot flushes were the most common symptom in both users and non-users and were the most frequent reason for prescribing HRT. The prevalence of menopausal symptoms in non-...

Both heart rate variability (HRV) and heart rate turbulence (HRT) are established tools to study cardiac autonomic activity. Short-term studies of HRV had been reported to be stable for autonomic function assessment. However, there is little information on whether short-term HRT assessment is comparable to 24 h assessment. The aim of the study is to identify the relationship of HRT values betwe...

An age-related decline in muscle performance is a known risk factor for falling, fracture and disability. In women, a clear deterioration is observed from early menopause. The effect of hormone replacement therapy (HRT) in preserving muscle performance is, however, unclear. This trial examined the effects of a 12-month HRT and high-impact physical exercise regimen on skeletal muscle in women in...