In the present work, Bilayered matrix type tablet were prepared by direct and wet granulation technique, in which immediate release layer ( compression) contains Nebivolol extended (by granulation) Nateglinide. All developed bilayer tablets evaluated for weight variation, friability, thickness hardness. The percent deviation from average weight, hardness was found to be within prescribed offici...

Objective: The present study’s is to develop floating drug delivery system of repaglinide. Methods: Moringa gum, Repaglinide, HPMC K100M, Sodium alginate, Calcium Carbonate, Citrate. obtained formulation was evaluated for content, pH, in vitro gelling capacity, buoyancy studies, and dissolution studies. Results Discussion: All the total F1-F12 formulations showed pH ranging from 5.1 7.9, lag ti...

1(NAFETIC) Centre, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, Andhra Pradesh, India. A b s t r a c t Ofloxacin (OFX) is a synthetic broad spectrum analog of second generation fluoroquinolone antibiotic. It is used for the treatment of urinary tract, prostate, skin, urinary and respiratory tract infections. Ornidazole (ORN) is a nitroimidazole derivativ...

It had became a challenging experience and effort for formulator to develop innovate drug with maximum bioavailability. In the present study focus of research is in treatment Hypertension, which one most prevalent cardiovascular diseases world, affecting big proportion adult old age population. Candesartan Cilexetil angiotensin II AT1 many tissues including vascular smooth muscle adrenal glands...

The goal of the present study was to develop inclusion complexes and polymers dispersions ramipril prepared by physical mixing, kneading, co-evaporation, solvent evaporation methods enhance drug solubility dissolution rate, thereby reduce dose side effects using selected hydrophilic carriers such as β-CD, PVP-K25, PEG 4000, HPMC K100M. formulations were characterized for in-vitro release studie...

In this study, aspirin (AS) and isosorbide 5mononitrate(ISM) sustained bilayer tablets were developed by wet granulation and compression technique, the influence of the contents of PVPP on the dissolution of AS from the tablets was investigated. An orthogonal experiment design was used to optimize ISM sustained release layer. The tablets were tested for their drug content, hardness, thickness, ...

Purpose: Ofloxacin is a fluoroquinolone with broad-spectrum antibacterial action, used in treatment of systemic and local infections. Ofloxacin is BCS class II drug having low solubility, high permeability with short half-life. The present work was aimed to design, develop and optimize gellified emulsion of Ofloxacin to provide site targeted drug delivery. Transdermal drug delivery will enhance...

Abstract Background The current study expands on the use of design experiment in developing cefuroxime axetil mucoadhesive minitablets for treating antibiotic-associated colitis. A comprehensive QbD-based product development strategy was implemented, with target profile defined based desired quality minitablets. identified critical attributes are profile. goal to find optimum levels by using co...

PURPOSE Bioadhesive polymers play an important role in biomedical and drug delivery applications. The aim of this study is to develop a sustained- release tablet for local application of Cetylpyridinium Chloride (CPC). This delivery system would supply the drug at an effective level for a long period of time, and thereby overcome the problem of the short retention time of CPC and could be used ...

Abstrak: Sediaan orally dissolving film (ODF) merupakan sebuah penemuan baru yang memungkinkan obat dapat digunakan secara nyaman dibandingkan sediaan solida oral lainnya tanpa memerlukan bantuan air minum. Pecut kuda (Stachytarpheta jamaicencis L.) salah satu tanaman herbal dikembangkan menjadi ODF dengan keuntungan memberikan waktu hancur cepat dan kenyamanan pengkonsumsian terutama pada pasi...