In the present study the effect of Hydroxypropyl methylcellulose (HPMC) added to predust and batters of Talang queen fish (Scomberoides commersonnianus) nugget on the quality and its shelf life during four months of frozen storage were evaluated. The treatments consisted of control (without HPMC in coating), A (with 2%HPMC in pre-dust), B (with 2%HPMC in batter) and C (with 1% HPMC in pre-dust ...

BACKGROUND The glucose degradation products (GDP) presentin conventional peritoneal dialysis fluids (PDF) may exert adverse effects toward human peritoneal mesothelial cells (HPMC). Some GDP can be detoxified by the glyoxalase/ glutathione pathway. It has been shown that the addition of glyoxalase I (GLO-I) and reduced glutathione (GSH) to PDF effectively eliminates GDP. We have therefore exami...

The present study performed by preparation and evaluation of floating tablets of Silymarin as model drug for prolongation of gastric residence time. Floating effervescent tablets were formulated by various materials like hydroxypropyl methylcellulose (HPMC) K 4M, K 15M, psyllium husk, swelling agent as crospovidone and microcrystalline cellulose and gas generating agent like sodium bicarbonate ...

A growing body of evidence indicates that epithelial-mesenchymal transition (EMT) of human peritoneal mesothelial cells (HPMC) may play an important role in the development and progression of peritoneal fibrosis during long-term peritoneal dialysis (PD) leading to failure of peritoneal membrane function. Here, we review our own observations and those of others on the mechanisms of EMT of HPMC a...

The purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. Polyethylene oxide (PEO) and hydroxypropyl methylcellulose (HPMC) were evaluated for matrix-forming properties. A simplex lattice design was applied to systemically optimize the drug release profile. The amounts of PEO WSR 303, HPMC K15M and sodium bicarbonate were selected as independen...

The object of this study was to assess the effects of the inflammatory cytokine interleukin 1β (IL-1β) (0.01–1.0 ng/ml) on the activity of catalase (CAT), superoxide dismutase (SOD) and the level o f glutathione (GSH), all being antioxidant mechanisms, in human peritoneal mesothelial cells (HPMC) in in vitro c ulture. HPMC were obtained from the omenta of nonuremic donors. The activity of the a...

Soybean enriched rice based gluten free breads were designed incorporating a structuring agent (hydroxypropylmethylcellulose HPMC) and a processing aid (transglutaminase TG). At dough level the effect of increasing amounts of soybean protein isolate (SPI), HPMC and water was studied in the Mixolab. Mixing and thermal characteristics showed the significant effect induced by water, soybean protei...

Study aims to design a Gastro retentive Drug Delivery System of Cefuroxime axetil (CA). CA is a broad spectrum beta lactam type of antibiotic. More specifically, it is a second-generation cephalosporin. CA has site specific absorption from upper gastro intestinal tract and in intestine it undergoes hydrolysis to cefuroxime having poor absorption. Unabsorbed drug causes high concentration of ant...

This Part I paper describes the qualification of a new high performance hypromellose (hydroxypropyl methylcellulose, HPMC) capsule shell which contains no gelling agent and is dissolution friendly. The development history and the test results for a series of quality attributes including scanning electron microscopy, hygroscopicity, machineability, weight variation, powder leakage, mechanical st...

Bioincompatibility of conventional glucose-based peritoneal dialysis fluids (PDF) has been partially attributed to the presence of glucose degradation products (GDP) generated during heat sterilization of PDF. Most previous studies on GDP toxicity were performed on animal and/or transformed cell lines, and the impact of GDP on peritoneal cells remains obscure. The short-term effects of six iden...