Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, USA *Corresponding author Mohtashem Samsam, MD, PhD Associate Professor of Medicine Burnett School of Biomedical Sciences College of Medicine University of Central Florida 4364 Scorpius St., HPA-II, 320 Orlando, FL 32816, USA Tel. 1407823 4810 Fax: 1407823 3095 E-mail: Mohtashem.Samsam@u...

Circulating angiotensin II (ANGII) elicits water intake and activates the hypothalamic-pituitary-adrenal (HPA) axis by stimulating angiotensin type 1 receptors (AT1Rs) within circumventricular organs. The subfornical organ (SFO) and the organum vasculosum of the lamina terminalis (OVLT) are circumventricular organs that express AT1Rs that bind blood-borne ANGII and stimulate integrative and eff...

Background and objective: According to the diathesis-stress model, disturbances of hypothalamic-pituitary-adrenal (HPA) axis are thought play a role in development, onset, progression psychosis. The aim this paper is present available body evidence on abnormalities cortisol awakening response (CAR) psychotic disorders at-risk states. Methods: Review literature from years 2011-2022 across three ...

DNA containing 5-azacytosine (azaC) has previously been shown to be a potent inhibitor of DNA-cytosine methyltransferases. In this report, we describe experiments which demonstrate that azaC-DNA forms a covalent complex with Hpa II methylase, a bacterial enzyme that methylates the internal C of C-C-G-G sequences. The complex does not undergo detectable dissociation over at least 3 days and is s...

This study aimed to examine the effects of different taping pressures with or without external force on the maximum dorsal flexion angle (DFA). Twenty-two healthy male university students with >5 years of athletic experience participated. A qualified trainer wound a rigid tape thrice around subject’s wrist joint. Taping pressure was measured using the pressure measuring system AMI3037-SB. Indep...

BACKGROUND Advanced glycation end products (AGEs), inflammatory-associated macrophage migration and accumulation are crucial for initiation and progression of diabetic vascular complication. Enzymatic activity of heparanase (HPA) is implicated strongly in dissemination of metastatic tumor cells and cells of the immune system. In addition, HPA enhances the phosphorylation of selected signaling m...

BACKGROUND AND PURPOSE Although risk factors for carotid artery stenosis caused by atherosclerosis are known, it is unclear what triggers "activation" of the atherosclerotic plaques and the ensuing thromboembolic cerebral events. The aim of this study was to evaluate whether thrombophilic factors, platelet glycoprotein (GP) polymorphisms, and homocysteine are associated with a risk of ischemic ...

AT(1) blockers attenuate hypothalamo-pituitary-adrenal (HPA) axis reactivity in hypertension independently of their potency to lower blood pressure. A reduced pituitary sensitivity to CRH and a downregulation of hypothalamic CRH expression have been suggested to influence HPA axis activity during chronic AT(1) blockade. This study was aimed at confirming the role of central angiotensin II in re...

The human platelet-specific alloantigens HPA-2a and HPA-2b (= Kob and Koa) together constitute a biallelic antigen system. The HPA-2 antigens have not, to date, been located on a particular platelet membrane molecule. Here, we describe the localization of these antigens on platelet glycoprotein (GP) Ib alpha. Platelets from two patients with the Bernard-Soulier syndrome (BSS) were HPA-2(a-,b-) ...