o-Hydroxyphenylacetaldehyde (o-HPA), the product of coumarin 3, 4-epoxide, was synthesized and its contribution to the hepatotoxic effects of coumarin in the rat was determined. The relative toxicity of coumarin and o-HPA were initially assessed in Chinese hamster ovary K1 (CHO K1) cells, a cell line that does not contain cytochrome P450. In CHO K1 cells, o-HPA-mediated toxicity greatly exceede...

3-Hydroxypropyl flufenamide (Flu-HPA) is one of a series of flufenamic acid derivatives that enhances blood clot lysis in vitro. Studies of possible mechanisms of action of FIu-HPA were undertaken. The profibrinolytic activity of FIu-HPA in clot lysis assays was found to be dependent on plasminogen. The influence of FIu-HPA on the ability of purified a2-antiplasmin to inhibit purified plasmin w...

In this paper, the satellite intermodulation is evaluated in frequency domain, for N-carrier input. Fourier transform is applied to avoid large equations where the number of carriers is quite low. The algorithm is probed with well-known series for particular cases with two input carriers. Additionally, it is also possible to evaluate AM-AM conversion in a large set of input carriers. Key-Words:...

T-cell responses have been implicated in the development of HPA-1a-induced neonatal alloimmune thrombocytopenia (NAIT). However, HPA-1a-specific T cells have neither been isolated nor characterized. Here, we aimed to determine whether HPA-1a-specific T cells could be isolated from HPA-1a-immunized women. In the present study, peripheral blood mononuclear cells (PBMCs) from an HPA-1a-alloimmuniz...

BACKGROUND This study analyses the relationship between the incidence of idiopathic spontaneous pneumothorax (ISP) and atmospheric pressure (AP). METHODS A total of 288 cases of ISP were included, 229 men and 59 women. The AP of the day of diagnosis, of the 3 prior days and the monthly average was registered. The association between the incidence of ISP and AP was analyzed by calculating stan...

Psychostimulants such as methamphetamine (MA) induce significant alterations in the function of the hypothalamic-pituitary-adrenal (HPA) axis. These changes in HPA axis function are associated with altered stress-related behaviors and might contribute to addictive processes such as relapse. In this mini-review we discuss acute and chronic effects of MA (adult and developmental exposure) on the ...

Dysregulation of hypothalamic-pituitary-adrenal axis (HPA) is seen in numerous mental disorders. Data of HPA axis disturbance in panic disorder are inconsistent. In panic disorder HPA axis hyperactivity has been observed with elevated cortisol levels. However, hypocortisolism has also been noted. Salivary cortisol as a biomarker of HPA-axis activity has received special attention. The aim of th...

Maternal alloantibodies against the human platelet Ag (HPA)-1a allotype of the platelet beta(3) integrin GpIIb/IIIa can cause severe fetal or neonatal hemorrhage. Almost all anti-HPA-1a-immune mothers are homozygous for HPA-1b and carry HLA-DR52a (DRB3*0101). The single Pro(33) -->Leu substitution (HPA-1b-->HPA-1a) was previously predicted to create a binding motif for HLA-DR52a that can lead t...

Results 342 of the patients were male and 42 were female. Mean age was 21.9±0.5 years old. Month (p=0.563), season (p=0.264) and weather (p=0.327) were not associated with the occurrence rate of SPM. Mean temperatures, mean humidity, mean wind velocities of SPM occurrence day and non-occurrence day were 12.4±10.5°C : 12.8±10.5° C (p=0.504), 61.8±15.5% : 60.9±15.0% (p=0.372), 2.6±1.0m/s : 2.6±2....