2-Pyridone (PD), converting to 2-hydroxypyridine (HP) through a lactam-lactim isomerization mechanism, can form three different cyclic dimers by hydrogen bond formation: (PD)(2), (PD-HP), and (HP)(2). We investigate the complexation chemistry of pyridone in dichloromethane-d(2) using a combined NMR and Fourier transform infrared (FT-IR) approach. Temperature-dependent (1)H NMR spectra indicate ...

AIM Hemoglobin (Hb) becomes toxic when released from the erythrocyte. The acute phase protein haptoglobin (Hp) binds avidly to Hb and decreases oxidative damage to Hb itself and to the surrounding proteins and lipids. However, the molecular mechanism underpinning Hp protection is to date unclear. The aim of this study was to use electron paramagnetic resonance (EPR) spectroscopy, stopped flow o...

We prove the quantum filtration on the Khovanov-Rozansky link cohomology Hp with a general degree (n + 1) monic potential polynomial p(x) is invariant under Reidemeister moves, and construct a spectral sequence converging to Hp that is invariant under Reidemeister moves, whose E1 term is isomorphic to the Khovanov-Rozansky sl(n)-cohomology Hn. Then we define a generalization of the Rasmussen in...

PURPOSE This article makes an attempt to synthesize certain compounds containing thiazole and imidazole moieties and screen for the antimicrobial properties. METHODS The novel compounds synthesized were characterized by elemental analysis, IR and (1)HNMR spectral data. The antimicrobial activity of novel compounds was evaluated by cup plate method. RESULTS The compound p-t showed more antib...

This paper presents the formulation, validation, and application of a spectral/hp algorithm for numerical solution of the Navier–Stokes and heat/scalar transport equations in arbitrarily moving complex geometries. The new spectral element algorithm is based on the arbitrary Lagrangian Eulerian formulation and utilizes modal expansion of Jacobi polynomials in mixed triangular and quadrilateral e...

Cardiac baroreflex is a fundamental component of the cardiovascular control. The continuous assessment of baroreflex sensitivity (BRS) from spontaneous heart period (HP) and systolic arterial pressure (SAP) variations during general anesthesia provides relevant information about cardiovascular regulation in physiological conditions. Unfortunately, several difficulties including unknown HP-SAP c...

Flavopiridol, the first inhibitor of cyclin-dependent kinases to enter clinical trials, has shown promising antineoplastic activity and is currently undergoing Phase II testing. Little is known about mechanisms of resistance to this agent. In the present study, we have characterized an ovarian carcinoma cell line [OV202 high passage (hp)] that spontaneously developed drug resistance upon prolon...