BACKGROUND Infectious diseases often demonstrate heterogeneity of transmission among host populations. This heterogeneity reduces the efficacy of control strategies, but also implies that focusing control strategies on "hotspots" of transmission could be highly effective. METHODS AND FINDINGS In order to identify hotspots of malaria transmission, we analysed longitudinal data on febrile malar...

this paper presents the results obtained from the life cycle assessment (lca) of the productionof sicilian artichokes (cynara scolymus) with the aim of reducing impacts, interpreting the results, suggesting possible improvements and enriching the sustainability knowledge already existing in the agro food field. artichokes represent one of the excellent italian agricultural products even if stil...

As advanced technologies in wafer manufacturing push patterning processes toward lower-k1 subwavelength printing, lithography for mass production potentially suffers from decreased patterning fidelity. This results in generation of many hotspots, which are actual device patterns with relatively large CD and image errors with respect to on-wafer targets. Hotspots can be formed under a variety of...

BACKGROUND Identifying ongoing tuberculosis infection sites is crucial for breaking chains of transmission in tuberculosis-prevalent urban areas. Previous studies have pointed out that detection of local accumulation of tuberculosis patients based on their residential addresses may be limited by a lack of matching between residences and tuberculosis infection sites. This study aimed to identify...

This paper compares two variants of the Knox test in relation to space-time crime pattern analysis. A case study of H┌ヴェノ;ヴ┞ ;ミS けstolen-┗WエキIノWげ crime data sets of San Francisco city is presented. The comparative analysis shows that while one variant is designed to detect the sizes of the spatio-temporal neighbourhoods at which clustering (hotspots) is prominent within a data set, the other va...

Meiotic crossover frequency varies extensively along chromosomes and is typically concentrated in hotspots. As recombination increases genetic diversity, hotspots are predicted to occur at immunity genes, where variation may be beneficial. A major component of plant immunity is recognition of pathogen Avirulence (Avr) effectors by resistance (R) genes that encode NBS-LRR domain proteins. Theref...

Spatial analyses of ecosystem system services that are directly relevant to both forest management decision making and conservation in the subtropics are rare. Also, frameworks that identify and map carbon stocks and corresponding forest management drivers using available regional, national, and international-level forest inventory datasets could provide insights into key forest structural char...

As technology scales, thermal issues are becoming a significant factor in chip design. Ever increasing transistor densities and increasing leakage currents result in high power dissipation, and require increasingly large and expensive cooling systems to maintain chip operating temperatures within safe bounds. Many existing thermal management techniques focus on reducing the overall power consum...

MOTIVATION There is much local variation in recombination rates across the human genome--with the majority of recombination occurring in recombination hotspots--short regions of around approximately 2 kb in length that have much higher recombination rates than neighbouring regions. Knowledge of this local variation is important, e.g. in the design and analysis of association studies for disease...

Objectives We aimed to evaluate the global scientific output of gene research of myocardial infarction and explore their hotspots and frontiers from 2001 to 2015, using bibliometric methods. Methods Articles about the gene research of myocardial infarction between 2001 and 2015 were retrieved from the Web of Science Core Collection (WoSCC). We used the bibliometric method and Citespace V to a...