نتایج جستجو برای: hotair

تعداد نتایج: 648  

2015
Ranran Wang Ying Shi Ling Chen Yiqun Jiang Chao Mao Bin Yan Shuang Liu Bin Shan Yongguang Tao Xiang Wang

The lncRNA HOTAIR is a critical regulator of cancer progression. Chromatin remodeling factor LSH is critical for normal development of plants and mammals. However, the underlying mechanisms causing this in cancer are not entirely clear. The functional diversification of the FOXA1 and FOXA2 contributes to the target genes during evolution and carcinogenesis. Little is known about the ratio of FO...

2017
Wen-Ming Chen Wei-Dong Chen Xue-Mei Jiang Xue-Feng Jia Hong-Mei Wang Qiu-Jie Zhang Yong-Qian Shu Hai-Bo Zhao

AIM To clarify the mechanisms of HOX transcript antisense intergenic RNA (HOTAIR) in gastric cancer (GC) migration and invasion. METHODS Quantitative real-time polymerase chain reaction (qPCR) was used to detect the expression level of HOTAIR in GC tissues. The correlation of its expression with clinicopathological features was analyzed. Area under receiver operating characteristic curve (AUC...

2015
HEE JUNG KIM DAE WOO LEE GA WON YIM EUN JI NAM SUNGHOON KIM SANG WUN KIM YOUNG TAE KIM

The functions of many long non-coding RNAs (lncRNAs) in human cancers remain to be clarified. The lncRNA Hox transcript antisense intergenic RNA (HOTAIR) has been reported to reprogram chromatin organization and promote breast and colorectal cancer metastasis, the involvement of lncRNAs in cervical cancer is just beginning to be studied. In the present study, we examined the expression and the ...

2016
Hua Zheng Jing Min

This study investigated the function of HOTAIR in the growth and apoptosis of OS MG-63 cell line in vitro and further clarified its mechanism. The expression levels of HOTAIR in OS MG-63 cell line and normal osteoblast hFOB1.19 cell line were determined by RT-PCR, respectively. The growth and apoptosis of MG-63 cells in vitro were investigated by MTT assay and flow cytometry assay after HOTAIR ...

2017
Xiaozhao Lu Danna Bai Xiangwei Liu Chen Zhou Guodong Yang

Pioneering epidemiological work has established strong association of sedentary lifestyle and obesity with the risk of colorectal cancer, while the detailed underlying mechanism remains unknown. Here we show that Hotair (HOX transcript antisense RNA) is a pro-adipogenic long non-coding RNA highly expressed in gluteal-femoral fat over other fat depots. Hotair knockout in adipose tissue results i...

2015
Yuan-Liang Wang Anne-Marie Overstreet Min-Shan Chen Jiang Wang Hua-Jun Zhao Po-Chun Ho Molly Smith Shao-Chun Wang

Triple-negative breast cancer (TNBC) does not express conventional therapeutic targets and is the only type of malignant breast cancer for which no designated FDA-approved targeted therapy is available. Although overexpression of epidermal growth factor receptor (EGFR) is frequently found in TNBC, the therapeutic effect of EGFR inhibitors in TNBC has been underwhelming. Here we show that co-tre...

Journal: :International journal of clinical and experimental pathology 2015
Weimin Zhao Mu Song Jie Zhang Mulati Kuerban Haijiang Wang

Long non-coding RNAs (lncRNAs) CCAT1 and HOTAIR have been shown to play an important regulatory role in cancer biology, and CCAT1 and HOTAIR are upregulated in several cancers, however, its value in the diagnosis of colorectal cancer (CRC) is unclear. Therefore, the aim of this study is to evaluate the clinical significance of plasma CCAT1 and HOTAIR as a biomarker in the screening of CRC. In o...

2018
Wenyan Zhao Donghua Geng Shuqiang Li Zhaofu Chen Ming Sun

To study the regulatory effect of lncRNA HOTAIR/miR-20a-5p/HMGA2 axis on breast cancer (BC) cell growth, cell mobility, invasiveness, and apoptosis. The microarray data of lncRNAs and mRNAs with differential expression in BC tissues were analyzed in the Cancer Genome Atlas (TCGA) database. LncRNA HOX transcript antisense RNA (lncRNA HOTAIR) expression in BC was assessed by qRT-PCR. Cell viabili...

Journal: :Journal of cancer science & therapy 2011
Mohammed M Milhem Tina Knutson Shujie Yang Danlin Zhu Xinjun Wang Kimberly K Leslie Xiangbing Meng

BACKGROUND Chemoresistance and metastasis are the main reasons for the failure of current treatments with sarcoma patients. Novel biomarkers are required to predict metastasis and response to treatment. The oncogene MTDH/AEG1 and the long noncoding RNA (lincRNA) HOTAIR are two novel factors involved in drug resistance and metastasis in various types of solid tumors. However, the correlation bet...

2016
Ana Rita Amândio Anamaria Necsulea Elisabeth Joye Bénédicte Mascrez Denis Duboule

Despite the crucial importance of Hox genes functions during animal development, the mechanisms that control their transcription in time and space are not yet fully understood. In this context, it was proposed that Hotair, a lncRNA transcribed from within the HoxC cluster regulates Hoxd gene expression in trans, through the targeting of Polycomb and consecutive transcriptional repression. This ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید