The utilization of hot melt extrusion (HME) technology for new applications is increasing in recent years, as evidenced by the many published reports last five years. Because its process automation and low-cost scale-up qualities, which decrease labor expenses capital investment. HME has emerged an essential drug delivery pharmaceutical research manufacture. novel application provides a promisi...

Taste is the ability to determine flavor of substances like food, drug, etc. The aspect taste only occurs when drug get soluble in saliva. Firstly gets dispersible saliva then they show interaction with bud and perception occurred. above test receptor binds molecules generates electrical impulses from area brain that cranial nerves 7th ,9th 10th occurs. Currently varieties drugs are available c...

The aim of this study was to evaluate the suitability of Raman spectroscopy as a Process Analytical Technology (PAT) tool for the in-line determination of the active pharmaceutical ingredient (API) concentration and the polymer-drug solid state during a pharmaceutical hot-melt extrusion process. For in-line API quantification, different metoprolol tartrate (MPT)--Eudragit® RL PO mixtures, conta...

Objective: Hot Melt Extrusion (HME) is one of the techniques for preparing a solid dispersion hydrophilic excipient known as no solvents practical method to increase solubility drugs. Apigenin (APG) has properties that thermal stable with melting point 345-350 °C but very low in water around 1,35 µg/ml. The polymer HME are Soluplus and Kollidon VA 64. study aims optimize kind formulae improve d...