A 36-year-old transgender man (assigned female at birth) on exogenous testosterone therapy was found to have stage IIA ovarian endometrioid carcinoma, and underwent adjuvant chemotherapy. Diffuse androgen receptor expression in the tumor initiated a multidisciplinary discussion regarding safety of continuing as gender-affirming hormone therapy.

Metastatic hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) breast cancer survival outcomes have improved significantly; however, once endocrine resistance develops, response rates to systemic treatments are limited. Within the developing field of antibody–drug conjugates, TROPiCS-02 study showed a significant improvement in progression-free with sacituz...

BACKGROUND Hormone receptors, including the estrogen receptor and progesterone receptor, human epidermal growth factor receptor 2 (HER2), and other biomarkers like Ki67, epidermal growth factor receptor (EGFR, also known as HER1), the androgen receptor, and p53, are key molecules in breast cancer. This study evaluated the relationship between HER2 and hormone receptors and explored the addition...

Abbreviations: BC: Before Christ; UV: Ultraviolet; NCBI: National Center For Biotechnology Information; Mirna: Microrna; IL-1: Interleukin 1; MSH: Melanocyte Stimulating Hormone; ACTH: Adrenocorticotropic Hormone; LH: Luteinizing Hormone; FSH: Follicle-Stimulating Hormone; MC1R: Melanocortin Type 1 Receptor; ER: Estrogen Receptor ; PR :Progesterone Receptor; TPO: Thyroid Peroxidase; TSH: Thyroi...

due to the increasing presence of electromagnetic radiation in advanced societies, investigation of the effects of this radiation on humans has attracted the interest of many researchers. the non- ionizing radiation can induce numerous effects through biomolecules in the tissue and cells. in the current study, effects of 12 hz electromagnetic waves investigated on neuronal hormone levels in rat...

The prevalence of thyroid diseases including autoimmune hyperthyroidism (Graves’ disease), thyroiditis, and different forms cancer is increasing every year, while the effectiveness their treatment remains low limited, mainly, to replacement therapy with hormones surgical radioisotope methods. This review presents current state problem pharmacological correction in new approaches regulation func...

Hormone binding to receptors on the cell surface triggers a sequence of events (receptor activation and signal generation) leading to activation of effectors in the cytoplasm. Receptor activation and signal generation are difficult to study as both are intimately associated with hormone binding. The lutropin-choriogonadotropin (LH/CG) receptor offers a unique model to differentiate and examine ...

Summary The three top abstracts at the 2020 virtual San Antonio Breast Cancer Symposium regarding hormone-receptor-positive early breast cancer, from our point of view, were long-awaited results Penelope B and RxPONDER as well data ADAPT trial West German Study Group. failed to show any benefit by adjuvant palbociclib when added standard endocrine therapy in patients without pathologic complete...

Fibroadenoma is the most prevalent benign breast tumor. It consists of epithelial and stromal components. In general, breast tumors are highly hormonally dependent and growth hormone by its physiology may have a possible oncogenic potential. Therefore, the aim of this study was to determine the expression of growth hormone and growth hormone receptor in epithelial and stromal components of fibr...

Ob-Rb: Long isoform of leptin receptor. Ob-Ra, Ob-RcÖOb-Rf: Short isoforms of leptin receptor. FSH: Follicle stimulating hormone. IGF-I: Insulin-like growth factor type 1. BCL-2: B-cell lymphoma 2. Bax: Bcl-2-associated X protein. DMEM: Dulbecco’s Modified Eagle Medium. ER: Estrogen receptor alpha. ER: Estrogen receptor beta. AR: Androgen receptor. LHR: Luteinizing hormone receptor. FSHR: Folli...