Drosophila enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) homology 1 (EVH1) domain proteins regulate signal transduction at the neuronal and immunologic synapse. Despite shared cell biologic machinery at these synapses, the regulation of client proteins that transmit synaptic activity to the nucleus is likely to be different. Homer-3, a member of the EVH1 family, is expressed in the t...

Drug addiction and reward learning both involve mechanisms in which reinforcing neuromodulators participate in changing synaptic strength. For example, dopamine receptor activation modulates corticostriatal plasticity through a mechanism involving the induction of the immediate early gene Homer 1a, the phosphorylation of metabotropic glutamate receptor 5 (mGluR5)'s Homer ligand, and the enhance...

We present HOMER, an analysis and visualization tool for ontology alignment. HOMER features a radial-graph display GUI, a complete execution trace that allows the user to override and navigate to any match decisions during at runtime and a comparison mode that displays multiple alignments in parallel. HOMER contains a builtin plugin for the ILIADS ontology alignment algorithm, but other algorit...

Store-operated channels are major calcium influx pathways in nonexitable cells. Homer scaffold proteins are well known for their role in regulating calcium signaling. Here we report on a detailed single-channel level characterization of native store-operated channels regulated by Homer scaffold proteins in A431 carcinoma cells. By applying the single-channel patch-clamp technique, we found that...

Homer protein was identified based on its rapid induction in rat hippocampal granule cell neurons following excitatory synaptic activity. Although the presence of the Homer gene in the peripheral tissues has been observed in previous reports, the physiological function of the Homer protein in these tissues has not been noted. In this experiment, a Homer-2a cDNA fragment was successfully amplifi...

Penelitian ini menjelaskan bagaimana menggunakan simulasi perangkat lunak Homer untuk menganalisa ekonomi PLTS ON GRID skala rumah tangga yang terhubung ke jaringan PLN. Nilai dicari dalam metode adalah harga dari Net Present Cost (NPC), of Energy (COE), Break Event Point pada 900 VA. Membandingkan nilai perhitungan faktor konsumsi energi sistem dengan biaya pemasangan PLN PV agar tercapai efis...

The objective of this research is to study the technical and economic performance of wind/diesel/battery (W/D/B) system supplying a remote small gathering of six families using HOMER software package. The electrical energy is to cater for the basic needs for which the daily load pattern is estimated. Net Present Cost (NPC) and Cost of Energy (COE) are used as economic criteria, wh measure of pe...