background: polycystic ovary syndrome (pcos), a common endocrine disorder, is associated with infertility, menstrual dysfunction, hirsutism and frequent miscarriages. insulin resistance, as a major cause of pcos, represents a disorder with increase in inflammatory markers and risk of type 2 diabetes. we aimed to investigate whether inflammatory markers, including c-reactive protein and c3 (comp...

OBJECTIVE To compare insulin resistance and glycemic indicators among subjects with euthyroidism and subclinical hypothyroidism. STUDY DESIGN Comparative cross-sectional study. PLACE AND DURATION OF STUDY Department of Pathology and Medicine, PNS Hafeez, Islamabad, in collaboration with the Department of Chemical Pathology and Endocrinology at the Armed Forces Institute of Pathology (AFIP),...

Adenosine deaminase (ADA) is an important regulator of insulin action. The single nucleotide polymorphism (SNP) G22A in the ADA gene decreases enzymatic activity of ADA. The aim of this study was to investigate the relationship between the SNP G22A and blood glycemic control, insulin resistance, and obesity of gestational diabetes mellitus (GDM) patients in an Iranian population. SNP G22A was d...

AIM To test the hypothesis that myoinositol supplementation will improve insulin sensitivity as measured by markers of insulin resistance such as homeostasis model assessment of insulin resistance and adiponectin in women with gestational diabetes. METHODS The trial was carried out in diet-treated patients with gestational diabetes diagnosed in our department between April 2008 and September ...

background: thiazolidinediones (tzds) improves insulin sensitivity by activating the peroxisome proliferator-activated receptor γ (ppar-g). we aimed to study any association between variation in bone biochemical markers and single nucleotide polymorphism (snp) in ppar- γ (pro12ala) and investigate if these genetic variants affect bone turnover markers in iranian diabetic population before and a...

RESEARCH DESIGN AND METHODSdWe used data from a population-based prospective cohort study among youth followed-up for up to 12 years (n = 317). In youth, maximal voluntary contractions during isometric back extension and abdominal flexion were determined using a strain-gauge dynamometer and CRF was obtained from a maximal cycle ergometer test. Insulin resistance (homeostasis model assessment of...

abstract objective: insulin resistance and hyperinsulinemia are common among the women with polycystic ovarian syndrome (pcos). familial aggregation of pcos has implications on the role of heredity in this disease. the aim of this study was to evaluate insulin resistance among the fathers, mothers, and siblings of the women with pcos referring to the clinics affiliated to shiraz university of m...

adenosine deaminase (ada) is an important regulator of insulin action. the single nucleotide polymorphism (snp) g22a in the ada gene decreases enzymatic activity of ada. the aim of this study was to investigate the relationship between the snp g22a and blood glycemic control, insulin resistance, and obesity of gestational diabetes mellitus (gdm) patients in an iranian population. snp g22a was d...