The limited localization and penetration of monoclonal antibodies (mAb) into solid tumors restricts their antitumor efficacy. Here, we describe a solid tumor-targeting antibody with enhanced tumor penetration activity. We designed a 22-residue peptide (A22p), which was extracted from the C-terminal basic region of semaphorin 3A (Sema3A) but modified to have higher affinity with neuropilin recep...

Internet wireless access technologies are increasingly heterogeneous. The main cause of this heterogeneity is that, up to now, no wireless technology has succeeded in widely conquering themarket. Nowadays, different access technologies co-exist in the same environment allowing multi-homed users to improve their experience by exploiting all available wireless interfaces. However, the energy cost...

It is proposed to implement a synchronised routing table at the transport layer, referred to as an Association Routing Table (ART), to improve the performance of multi-homed transport protocols. An algorithm is described that ensures that the routing tables can be synchronised, which is then used to implement a handover mechanism. The ART is implemented within SCTP. It is shown that by using a ...

As a transport layer protocol SCTP uses end to end metrics, such as Retransmission Time Out (RTO), to manage mobility handover. Our investigation illustrates that Wireless LAN (WLAN) mobility causes continuously increased Round Trip Times (RTT) resulting from 802.11 MAC retransmissions, regardless of the service specified by upper layers. We present scenarios where the current understanding of ...

The widespread deployment of various networking technologies, coupled with the exponential increase in end-user data demand, have led to the proliferation of multi-homed, or multi-interface enabled, devices. These trends drove researchers to investigate a wide spectrum of solutions, at different layers of the protocol stack, that utilize available interfaces in such devices by aggregating their...

This paper outlines initial analysis from research in progress into ADSL homed Nepenthes honeypots. One of the Nepenthes honeypots prime objective in this research was the collection of malware for analysis and dissection. A further objective is the analysis of risks that are circulating within ISP networks in Western Australian. What differentiates Nepenthes from many traditional honeypot desi...

Extended abstract. Network address translation poses a challenge for hosts that attempt to use protocols that place internet protocol addressing information inside IP payload. The same issue exists for the Stream Control Transmission Protocol and is even more difficult when SCTP associations are multi-homed. This paper deals with the options available for establishment of an SCTP association be...

Multi-homing, or direct attachment to multiple networks, offers both performance and availability benefits for important servers on busy networks. Exploiting these benefits to their fullest requires a modicum of routing knowledge in the clients. Careful policy control must also be reflected in the routing used within the network to make best use of specialized and often scarce resources. While ...

Follicular Tregs (Tfr cells) inhibit antibody production, whereas follicular Th cells (Tfh cells) stimulate it. Tfr cells are found in blood; however, relatively little is known about the developmental signals for these cells or their functions. Here we demonstrated that circulating Tfr and Tfh cells share properties of memory cells and are distinct from effector Tfr and Tfh cells found within ...

Hematopoietic stem cell (HSC) niches have been reported at the endosteum or adjacent to bone marrow (BM) vasculature. To investigate functional attributes of these niches, mice were perfused with Hoechst 33342 (Ho) in vivo before BM cell collection in presence of pump inhibitors and antibody stained. We report that the position of phenotypic HSCs, multipotent and myeloid progenitors relative to...