INTRODUCTION A physically active life-style plays an independent role in the protection against type 2 diabetes and cardiovascular diseases. Irisin, a novel exercise-induced myokine, activates thermogenesis in rodents through increasing beige fat cells abundance within white fat. We aimed to investigate circulating irisin levels in association with the degree of physical activity and various me...

BACKGROUND Chinese immigrants experience increased chronic disease risk following migration to the US. Although the impact of lifestyle changes (e.g., diet) on disease risk has been extensively studied, associations of psychosocial stress and disease risk have attracted less attention. Thus, the objective of the present study was to examine associations between stress and insulin resistance in ...

INTRODUCTION The epidemic of metabolic syndrome is increasing worldwide and correlates with elevation in serum uric acid and marked increase in total fructose intake. Fructose raises uric acid and the latter inhibits nitric oxide bioavailability. We hypothesized that fructose-induced hyperuricemia may have a pathogenic role in metabolic syndrome and treatment of hyperuricemia or increased nitri...

BACKGROUND Published studies showed conflicting results of the associations between adiponectin and leptin levels and obstructive sleep apnoea (OSA). In obese patients, plasma leptin is elevated and adiponectin is decreased, and we postulate that these adipokines could be potential markers of clinical and metabolic perturbations in patients with OSA. METHODS 147 patients with suspected OSA ha...

OBJECTIVE To assess the utility of HOMA-IR in assessing insulin resistance in patients with polycystic ovary syndrome (PCOS) and compare it with fasting insulin for assessing insulin resistance (IR). STUDY DESIGN Observational study. PLACE AND DURATION OF STUDY Section of Clinical Chemistry, Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Karachi, from Jan...

Obesity is a main reason of type 2 diabetes and also chronic exposure to arsenic (As)can produce diabetic symptoms. In previous studies, the association between high-fat dietand arsenic in the incidence of diabetes was found, but the role of beta cells activity, livermitochondrial oxidative stress, and hepatic enzymes (leptin, adiponectin and beta amylase)was unclear. Thus, present study was co...

Abstract Background Preeclampsia, a hypertensive pregnancy disorder, is strongly associated with aberrant left ventricular remodelling up to ten years after delivery and heart failure later in life. To detect occult cardiac abnormalities, echocardiography necessary but not feasible for all these women. A prediction model be used primary care may guide towards intensified follow-up those at risk...

Obesity is a main reason of type 2 diabetes and also chronic exposure to arsenic (As)can produce diabetic symptoms. In previous studies, the association between high-fat dietand arsenic in the incidence of diabetes was found, but the role of beta cells activity, livermitochondrial oxidative stress, and hepatic enzymes (leptin, adiponectin and beta amylase)was unclear. Thus, present study was co...

To determine the association between serum levels of OCN and metabolic parameters carotid intima media thickness (CIMT) in a group post-menopausal females with type 2 diabetes (T2DM). This cross-sectional study comprised 75 postmenopausal women T2DM (group 1; 25 patients normal bone mineral density (BMD), 2; osteopenia 3; osteoporosis) 40 age matched non-diabetic females. All subjects included ...

esistin, an adipocyte secreted hormone, has been suggested to link obesity with type 2 diabetes and insulin resistance in rodent models, but its relevance to human diabetes remains uncertain. The aim of this study was to investigate the relationship between serum resistin concentrations with markers of insulin resistance and obesity in type 2 diabetes and non-diabetic obese subjects. Materials ...