AIM As transcutaneous electrical stimulation (TES) increased defecation in children and adults with Slow-Transit Constipation (STC), we performed a pilot study to test if TES can improve symptoms (defecation and soiling) in children with chronic constipation without STC and transit delay in the anorectum. METHODS Children with treatment-resistant constipation presenting to a tertiary hospital...

Some recent literature has concluded that patent remedies result in systematically excessive royalties because of holdup and stacking problems. This article shows that this literature is mistaken. The royalty rates predicted by the holdup models are often (plausibly most of the time) below the true optimal rate. Further, those predicted royalty rates are overstated because of incorrect assumpti...

Volumetric mass transfer coefficient (kLa) is an important parameter in bioreactors handling viscous fermentations such as xanthan gum production, as it affects the reactor performance and productivity. Published literatures showed that adding an organic phase such as hydrocarbons or vegetable oil could increase the kLa. The present study opted for palm oil as the organic phase as it is plentif...

In this work, the dispersed phase holdup in a Kühni extraction column is predicted using intelligent methods and a new empirical correlation. Intelligent techniques, including multilayer perceptron and radial basis functions network are used in the prediction of the dispersed phase holdup. To design the network structure and train and test the networks, 174 sets of experimental data are used. T...

In the gas-water two phase of horizontal well, gas holdup is usually obtained by inverse calculation water measured array capacitance probes. Gas Array Tool (GAT) has been developed to directly measure holdup. This instrument introduced into China and its simulation experiment in flow wells carried out for first time study applicability measurement. Firstly, response principle measurement metho...

When innovation is cumulative, early patentees can hold up later innovators. Under complete information, licensing before R&D avoids holdup. But when development costs are private information, ex ante licensing may only occur in regimes with sub-optimal patent policy.

We study several interconnected problems that arise under the current U.S. patent system when a patent covers one component or feature of a complex product. This situation is common in the information technology sector of the economy. Our analysis applies to cases involving reasonable royalties but not lost profits. First, we show using bargaining theory that the threat to obtain a permanent in...