BACKGROUND The effect of the redox state of human serum albumin (HSA) on the antioxidant properties of the entire body has been a focus of recent research. The usefulness of HSA redox state as a biomarker for reducing oxidative stress has been investigated in clinical settings; however, evidence for its significance as a health index in non-clinical settings is yet to be established. This study...

Attentional bias toward threatening or emotional information is considered a cognitive marker of anxiety, and it has been described in various clinical and subclinical populations. This study used an emotional Stroop task to investigate whether math anxiety is characterized by an attentional bias toward math-related words. Two previous studies failed to observe such an effect in math-anxious in...

Mitochondria, the powerhouses of eukaryotic cells, regulate many pathways related to cell growth and division. They also participate in apoptotic cell death and survival pathways such as autophagy and in innate immune responses. As such, mitochondria are a tempting target for intracellular pathogens, which may seek to block or manipulate mitochondrial activity to meet their own needs. Sometimes...

We studied the actions of geldanamycin (GA) and herbimycin A (HMA), inhibitors of the chaperone proteins Hsp90 and GRP94, on B chronic lymphocytic leukemia (CLL) cells in vitro. Both drugs induced apoptosis of the majority of CLL isolates studied. Whereas exposure to 4-hour pulses of 30 to 100 nM GA killed normal B lymphocytes and CLL cells with similar dose responses, T lymphocytes from health...

Hot-mix asphalt (HMA) surfaces comprise about 90% of the highways and roads in the U.S. Highways and are typically engineered to last 15 years or more, but many have been failing early due to potholes, cracks, raveling, and other problems. This premature road failure unnecessarily wastes millions of taxpayer dollars every year. This paper describes a series of research studies that were conduct...

The gp120 region of the human immunodeficiency virus type 1 (HIV-1) envelope (env) gene exhibits a high level of genetic heterogeneity across the group M subtypes. The heteroduplex mobility assay (HMA) has successfully been used to assign subtype classifications, but C2V5 primers often fail to amplify African strains. We developed an env gp41-based HMA for which the target sequence is amplified...

There has been a concentrated effort in modeling fluid flow in asphalt pavements, and most of the existing work has been limited to evaluation of directional permeabilities. The effects of other phenomena, such as development of flow-induced pore pressure and viscous shear stress distributions at the pore–solid interfaces, on moisture damage in an asphalt pore structure have not been fully unde...

Marine sponges host bacterial communities with important ecological and economic roles in nature and society, yet these benefits depend largely on the stability of host-symbiont interactions and their susceptibility to changing environmental conditions. Here, we investigated the temporal stability of complex host-microbe symbioses in a temperate, seasonal environment over three years, targeting...

Hot Mix Asphalt (HMA) paving of airport runways mostly requires multiple paving teams, multiple pavers, and a wide array of other equipment. The runway paving projects are typically renowned for the logistical effort and the tight margins for overruns, often requiring a relatively large part of the contractor’s resources. Due to the nature of airport operations the projects are of a fast-track ...