background: it has been arguedthat unprecedented degree of human leukocyte antigen (hla) loci polymorphism within a population is requiredto avoid the devastating effects of infectious diseases. the present study was conducted to determine the associations between some of hla classi genes and the outcome of hepatitis b virus (hbv) infection.   methods: using sequential sampling method, 64 indiv...

background: during antigen capture and processing, mature dendritic cells (dc) express large amounts of peptide-mhc complexes and accessory molecules on their surface. dc are antigen-presenting cells that have an important role in tolerance and autoimmunity. the transforming growth factor-beta1 (tgf-β1) cytokine has a regulatory role on the immune and non-immune cells. the aim of this study is ...

Abstract Background iPSC (induced pluripotent stem cells) banks of lines with homozygous HLA (human leukocyte antigen) haplotypes (haplobanks) are proposed as an affordable and off-the-shelf approach to allogeneic transplantation derived cell therapies. Cord blood offer extensive source HLA-typed cells suitable for reprogramming iPSC. Several initiatives worldwide have been undertaken create na...

Background: Human leukocyte antigen (HLA) complex is a gene family involved in antigen presentation associated with protection or susceptibility to inflammatory, infectious and autoimmune diseases. Atherosclerosis is a chronic inflammatory disease in which HLA molecules play a role in the initiation and development of the disease through presentation of self or foreign antigens to T cells. Obje...

the object of this cross sectional study was to determine the hcv subtype 3a envelope protein binding affinity with human leukocyte antigen. envelope 1 (e1) protein is one of the structural proteins responsible for entering the cells through the receptors. the binding affinity of e1 protein epitopes to the selected human leukocyte antigen (hla) class i alleles was investigated using the compute...

Abstract Immunotherapeutic approaches in cancer aim to booster T cell mediated immune responses. Tumor-specific cells recognize target via human leukocyte antigen (HLA) molecules before specific lysis is initiated. Malignant gliomas are known for their immunoevasive and immunosuppressive properties which impede effective tumor-specific responses, including clinical responses checkpoint inhibiti...

Progression of oral squamous cell carcinoma (OSCC) has been associated with an escape tumor cells from the host immune surveillance due to increased knowledge its underlying molecular mechanisms and modulation by microenvironment repertoire. In this study, expression HLA class I (HLA-I) antigens components antigen processing machinery (APM) was analyzed in 160 pathologically classified human pa...

the human leukocyte antigen-b27 is one of the class i molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (as) . the strength of the disease association with b27 varies markedly among racial and ethnic populations. it is an allele family, which constitutes about 31 subtypes, with a considerable geographic and ethnic difference in distributi...

To investigate the human leukocyte antigen (HLA) association with anti-synthetase syndrome (ASSD). We conducted largest immunogenetic HLA-DRB1 and HLA-B study to date in a homogeneous cohort of 168 Caucasian patients ASSD 486 ethnically matched healthy controls by sequencing-based-typing. A statistically significant increase HLA-DRB1*03:01 HLA-B*08:01 alleles compared was disclosed (26.2% versu...