background: nasal inflammatory disorders such as chronic rhinosinusitis and nasal polyp are among the most prevalent complications with high socioeconomic costs. vascular endothelial growth factor (vegf) plays a key role in angiogenesis and cell proliferation. in the present study the effect of vegf on the development and prognosis of chronic rhinosinusitis and nasal polyp was investigated. met...

Objective: There is evidence that gestational exposure to lipopolysaccharide (LPS) results in fetal zinc deficiency, and eventually neurodevelopmental abnormalities. In this study, we utilized a rat model of maternal immune activation (MIA) to investigate the possible neuroprotective effect of zinc supplementation throughout pregnancy on hippocampal astrocytes activation as well as inflammatory...

Objective: High-fat diet (HFD) rises the susceptibility of both obesity and consequently Inflammatory Bowel Disease (IBD). We designed a study to investigate the improving effects of herbal extract (HE, the combination of turmeric, ginger, boswellia, and cat’s claw extract) on the risk of high AGEs-fat diet 60% (HFD) mice induced colitis and obesity. Materials and Methods: Four-week-old C57BL/...

Background: Nasal inflammatory disorders such as chronic rhinosinusitis and nasal polyp are among the most prevalent complications with high socioeconomic costs. Vascular Endothelial Growth Factor (VEGF) plays a key role in angiogenesis and cell proliferation. In the present study the effect of VEGF on the development and prognosis of chronic rhinosinusitis and nasal p...

Abstract The natural byproduct Cinnamomum cassia was widely used in ancient Asia to cure disease because of its various pharmacological effects. Despite ethnomedicinal benefits, few studies on the intestinal anti-inflammatory effect C. have been reported. Therefore, this study aimed evaluate potential beneficial effects intestine vitro and vivo. Herein, cinnamon hot water extract (CWE) tight ju...

To elucidate carcinogenesis in the endometrium, we investigated cyclin D1 immunoreactivities in 20 normal endometria, 20 endometrial hyperplasias and 141 endometrioid-type endometrial adenocarcinoma. We also evaluated the correlation of cyclin D1 expression with Ki-67, cyclin E, cyclin A, cdk2, p27 and p53, and clinicopathological parameters and prognosis. Cyclin D1 expression increased signifi...

background and aims. mineral trioxide aggregate and calcium hydroxide are considered the gold standard pulp-capping materials. recently, portland cement has been introduced with properties similar to those of mineral trioxide aggregate. histopathological effects of direct pulp capping using mineral trioxide aggregate and portland cements on dog dental pulp tissue were evaluated in the present s...

Background: Hypothyroidism is a decrease in the production of thyroid hormones and leads to gland dysfunction. Ashwagandha extract was used as an ayurvedic treatment supposed be antihypothyroidism agent. Objectives: investigate impact ashwagandha (Ash) on propylthiouracil (PTU)-induced hypothyroidism rats. Subjects Methods: The rats were divided into three groups, control group, PTU (hypothyroi...

there is an impression that basal cell carcinomas (bcc) occurring in younger population may be of more invasive behavior in comparison to those arising in older patients. the purpose of this study was to investigate this hypothesis by comparing the histological types of bcc in a large cohort of young and old patients. a total of 287 histological reports and clinical records were evaluated. a co...