Gastric bleeding due to graft-vs-host-disease (GVHD) is rare after allogeneic hematopoietic stem cell transplantation, and the interrelationship between endoscopic and histologic assessment has not been well studied. Four patients with documented gastric bleeding due to GVHD were evaluated retrospectively. The endoscopic findings varied markedly and included mild mucosal edema with focal erythe...

BACKGROUND AND PURPOSE There are, to our knowledge, no histologic data correlating aneurysm volume with histologic healing following coil embolization of aneurysms. We report a retrospective study comparing histologic outcome with aneurysm volume in elastase-induced aneurysms in rabbits. MATERIALS AND METHODS Aneurysm volume and histologic healing after coil embolization were retrospectively ...

The article reviews the controversial area of poorly differentiated thyroid carcinoma. Consensus criteria that define poorly differentiated thyroid carcinoma have been published in 2007. According to these, poorly differentiated thyroid carcinoma is a distinct histotype and the term "poorly differentiated" should not be used as a synonym for high-grade thyroid cancer. Data in the literature sho...

BACKGROUND AND PURPOSE Histologic grading of intracranial astrocytomas is affected by sampling error and substantial inter- and intraobserver variability. We proposed that incorporating MR imaging into grading will predict patient survival more accurately than histopathology alone. MATERIALS AND METHODS Patients with a new diagnosis of World Health Organization grades II-IV astrocytoma or mix...

Background-Histologic grading has been used as a prognostic factor and for clinical behavior evaluation of oral squamous cell carcinoma (SCC) for the past several decades. At the same time, the prognostic value of different grading classifications remains controversial. Methods-A retrospective study of 48 cases of tongue SCC was undertaken to compare different grading systems and their relation...

The clinical usefulness of histologic grading in follicular lymphoma (FL) is controversial and is further compromised by the subjective nature and poor reproducibility of most systems in current use. Therefore, we decided to objectively evaluate the importance of cellular proliferation in FL, along with the current grading systems. We studied 106 patients with FL who were uniformly staged and a...

The retinoblastoma family consists of the tumor suppressor nuclear phosphoprotein pRb/p105 and related proteins p107 and pRb2/p130. Recent immunohistochemical studies of the retinoblastoma family of proteins in lung and endometrial cancer and choroidal melanomas show a tight inverse correlation between the histologic grading in the most aggressive tumor types and pRb2/p130 expression. This led ...

BACKGROUND Gliomas are grouped into grades 1 to 4 on the basis of morphologic criteria. Grade is the most significant prognostic factor determining survival, but various proliferation markers are being increasingly employed by histopathologists as adjuncts to conventional morphologic variables to determine prognostic behavior of brain tumors. The most widely used and useful of these are MIB1 (K...

PURPOSE To evaluate 20 cases of nonmetastatic synovial sarcoma of the extremities regarding prognostic factors, and to propose a histologic grading system with prognostic significance. METHODS The cases of 20 patients (14 females and 6 males) with nonmetastatic synovial sarcomas of the extremities treated between 1985 and 1998, were retrospectively evaluated regarding prognostic factors. A hi...

Attempting to establish more objective grading system of renal cell carcinoma, I studied 104 renal cell carcinoma tissue samples from 52 cases by immunohistochemical technique employing the anti-Leu M1 antibody and the anti-EMA antibody. These 52 cases could be classified into 4 groups according to the reactivity for Leu-M1 (L) and EMA (E), i.e., L+E-, L+E+, L-E+, and L-E-. Considering the expr...