Vertebral Langerhans cell histiocytosis, formerly called Histiocytosis X, is rarely seen in adults: a systematic non-quantitative review of the literature yielded only 27 cases. Vertebra plana is often associated in children, but this is not a feature in the adult population. The authors report the case of a 29-year-old woman with a two-month history of lumbar pain. Osteolysis of the right pedi...

Pulmonary Langerhans’ cell histiocytosis (LCH)/histiocytosis X is a rare smoking-related interstitial lung disease that predominantly affects adults aged 20–40 yrs. It is commonly associated with irreversible airflow obstruction and highly variable clinical outcomes. The disease may regress spontaneously or following smoking cessation; however, in 20–30% of cases it progresses to chronic respir...

Langerhan’s Cell Histiocytosis formerly known as histiocytosis X traditionally denotes a group of diseases that stem from proliferative reticuloendothelial disturbances. The etiology and pathogenesis of the disease remain debatable.The present paper reports a case occuring in a three and a half year old ( 31⁄2 year pediatric) child reported to the department of oral pathology with gingival enla...

A boy with histiocytosis X, first diagnosed at the age of 9 months, presented at the age of 5 years with left globe luxation. Under general anaesthesia the globe was reduced and a temporary paracentral tarsorrhaphy carried out. He was started on a course of oral steroids. Two years later he had normal visual acuity, full ocular movements, and healthy fundi.

BACKGROUND Isolated mediastinal involvement in Langerhans cell histiocytosis (LCH) has been rarely reported. CASE CHARACTERISTICS A 3-month-old boy presented with history of low grade intermittent fever, cough and noisy breathing for 2 weeks. OBSERVATION A chest X-ray showed massive mediastinal widening. Biopsy of the mass confirmed LCH. OUTCOME Patient is doing well after one year of tre...