Hirschsprung disease in adults is a rare and frequently misdiagnosed cause of long-standing refractory constipation. Surgical procedures initially developed for pediatric patients are applied to with varying degrees success. A nineteen-year-old girl was diagnosed tertiary hospital low technology level Togo. Soave-Boley’s procedure used as definitive surgical management which resulted good outco...

Distinct point mutations in the RET proto-oncogene are the cause of the inherited multiple endocrine neoplasia type 2 syndromes (MEN 2), and the congenital gut disorder Hirschsprung disease. The site and type of these mutations suggests that they have differing effects on the activity of the receptor tyrosine kinase encoded by RET. The normal function of the RET receptor tyrosine kinase has yet...