purpose of this study was to investigate the effect of the presence of the water soluble polymers viz hpmc, pvp and peg 6000 on aqueous solubility and complexation abilities of felodipine with or without presence of β-cyclodextrin (βcd) and hpβcd by phase solubility studies. the data revealed the initial increase in drug solubility followed by plateau in the presence of relatively low polymer c...

Purpose: To prepare oral sustained release matrix tablets of a highly water soluble drug, tramadol hydrochloride, and to evaluate the effect of concentration of the hydrophobic polymer content and method of preparation on drug release. Methods: The tablets were a mixture of both tramadol hydrochloride and glyceryl palmitostearate (GP) prepared by melt granulation (MG1, MG2, MG3 and MG4 in ratio...

       The purpose of this review article is to characterize all of the parameters regarding the types, polymers used, and release kinetics of matrix tablets. Matrix system was the earliest oral extended release platform for medicinal use. Matrix tablets are most commonly used methods to modulate the release profile of drugs. They are much desirable and preferred for such therapy because they o...

The study was aimed at developing extended release matrix tablets of poorly water-soluble diclofenac sodium and highly water-soluble metformin hydrochloride by direct compression using cashew gum, xanthan gum and hydroxypropylmethylcellulose (HPMC) as release retardants. The suitability of light grade cashew gum as a direct compression excipient was studied using the SeDeM Diagram Expert System...

       Purpose of this study was to investigate the effect of the presence of the water soluble polymers viz HPMC, PVP and PEG 6000 on aqueous solubility and complexation abilities of felodipine with or without presence of β-cyclodextrin (βCD) and HPβCD by phase solubility studies. The data revealed the initial increase in drug solubility followed by plateau in t...

Department of pharmaceutics, Hindu College of Pharmacy, Guntur, Andhra Pradesh, India. ______________________________________________________________________ ABSTRACT Poorly water-soluble drugs involve many difficulties in the development of pharmaceutical dosage forms for oral delivery systems due to their low bioavailability. Therapeutic effectiveness of a drug depends upon the bioavailabilit...

et al. (1948) used 3 per cent ethyl-alcohol for dissolving the insoluble drugs before adding to their synthetic media. With both the above methods the drug does get uniformly distributed in the media but gets ultimately precipitated if it is highly insoluble. The drugs reported in this paper are mostly insoluble in water beyond a dilution of 1 in 10,000 and are soluble in alcohol in a minimum o...