We present a unified approach to modelling dyadic relational data, namely that seen in social, biological and technological networks, without restriction to the binary format. The approach involves three principles: considering the marginal specification of any edge as the fundamental unit, embedding as much dependence as possible in latent structural forms, and using distributional forms that ...

Feature reduction is a major preprocessing step in the analysis of highdimensional data, particularly from biomolecular high-throughput technologies. Reduction techniques are expected to preserve the relevant characteristics of the data, such as neighbourhood relations. We investigate the neighbourhood preservation properties of feature reduction empirically and theoretically. Our results indic...

38 LLE Review, Volume 73 A major roadblock to rapid progress in laser fusion is the enormous price of the necessary experimental facilities. Currently under planning or nearing construction are 40-cm-clearaperture (per beam line), 200-or-more-channel, glass-laser systems that will each cost in excess of U.S. $109 in pursuit of laser-fusion research.1 A sizable portion of this price bears witnes...

Motivation: Nanopore sequencers are emerging as promising new platforms for high-throughput sequencing. As with other technologies, sequencer errors pose a major challenge for their effective use. In this paper, we present a novel information theoretic analysis of the impact of insertion-deletion (InDel) errors in nanopore sequencers. In particular, we consider the following problems: (i) for g...

In previous work we have shown how a max-plus algebraic model can be derived for cyclically operated high-throughput screening systems and how such a model can be used to design a controller to handle unexpected deviations from the predetermined cyclic operation during runtime. In this paper, we introduce an extension of this approach for high-throughput screening systems containing multi-capac...

Droplet manipulation is comprised of techniques such as droplet generation, merging, and splitting, of which droplet merging is one of the major bottlenecks in achieving high-throughput analysis. Here we present a three dimensional electrode that improves the electric field uniformity and field strength experienced by two adjacent droplets undergoing merging. We conducted a systematic compariso...

The accumulating genome sequences and other high-throughput data have shed light on the extent and importance of alternative splicing in functional regulation. Alternative splicing dramatically increases the transcriptome and proteome diversity of higher organisms by producing multiple splice variants from different combinations of exons. It has an important role in many biological processes in...

We present an image analysis approach as part of a highthroughput microscopy screening system based on cell arrays for the identification of genes involved in Hepatitis C and Dengue virus replication. Our approach comprises: cell nucleus segmentation, quantification of virus replication level in cells, localization of regions with transfected cells, cell classification by infection status, and ...