In its fifth decade of existence, the construct of schizotypy is recapturing the early scientific interest it attracted when Paul E. Meehl (1920-2003), who coined the term, pioneered the field of schizotypy research. The International Lemanic Workshop on Schizotypy, hosted at the University of Geneva in December 2013, recently offered an opportunity to address some of the fundamental questions ...

Disorganized speech in both schizophrenia and schizotypy has been hypothesized to result from abnormalities in how concepts activate one another in semantic memory. To study whether schizotypy is associated with differences in how categories activate their exemplars, we examined the N400 component of the event-related brain potential (ERP) elicited during a category-verification task. ERPs were...

BACKGROUND The disorganized and negative dimensions of schizotypy are characterized by cognitive disorganization and anhedonia, respectively. The aim of the study was to investigate the relationships between these two dimensions of schizotypy by taking into account ambivalence and the distinction between consummatory and anticipatory anhedonia. METHODS Dimensional analysis and categorical ana...

This research examined whether facets of schizotypy were differentially related to cognitive control and emotion-processing traits. In a confirmatory factor analysis (N = 261), a 3-factor model of schizotypy exhibited good fit and fit significantly better than a 2-factor model. In addition, only disorganized schizotypy was associated with poor cognitive control (specifically, prepotent inhibiti...

Schizotypy is a multidimensional personality construct that is characterized by perceptual abnormalities, social withdrawal, mild suspiciousness, and odd thinking patterns. This study examined the relationship between four dimensions of self-reported schizotypy and substance use involving nicotine, alcohol, and cannabis, in undergraduate students. Results showed that higher levels of disorganiz...

BACKGROUND AND OBJECTIVES Individuals who score high on positive schizotypy personality traits are vulnerable to more frequent trauma-related intrusive memories after a stressful event. This vulnerability may be the product of a low level of contextual integration of non-stressful material combined with a heightened sensitivity to a further reduction in contextual integration during a stressful...

The development of drugs to improve cognition in patients with schizophrenia is a major unmet clinical need. A number of promising compounds failed in recent clinical trials, a pattern linked to poor translation between preclinical and clinical stages of drug development. Seeking proof of efficacy in early Phase 1 studies in surrogate patient populations (for example, high schizotypy individual...

• Rejection sensitivity (RS) is positively associated with both schizotypy and aggression. Elevated RS in people high may be explained by disorganisation social anxiety. aggression anger the need to retaliate repair mood. Multimodal studies ecologically valid paradigms are needed investigate how RS, might co-exist at brain behavioural levels. expectation of being distanced from excluded others,...

The present study examined the factor structure underlying the Wisconsin Schizotypy Scales and the validity of these dimensions. Confirmatory factor analysis with 6137 nonclinical young adults supported a 2-factor model with positive and negative schizotypy dimensions. As predicted, the schizotypy dimensions were differentially related to psychopathology, personality, and social impairment. Bot...