BACKGROUND The aim of this study was to explore the influence of extended-release niacin/laropiprant (ERN/LRP) versus placebo on high-density lipoprotein (HDL) antioxidant function, cholesterol efflux, apolipoprotein B100 (apoB)-containing lipoproteins, and mediators of vascular inflammation associated with 15% increase in high-density lipoprotein cholesterol (HDL-C). Study patients had persist...

We studied the precipitation of isolated lipoproteins with heparin and MnCl2. Lipoproteins were isolated from human plasma by preparative ultracentrifugation and their free cholesterol was labeled. Each lipoprotein fraction was then precipitated at various pHs, with or without bovine serum albumin (60 g/L) present. Under no set of conditions was one class of lipoproteins completely separated fr...

High density lipoprotein (HDL) binding to human fibroblasts and arterial smooth muscle cells is up-regulated when sterol is delivered to cells in the form of nonlipoprotein cholesterol or low density lipoprotein (LDL). Results from the present study show that the HDL binding activity of aortic endothelial cells is up-regulated when cholesterol in the form of acetylated LDL (AcLDL) is delivered ...

Familial Hypercholesterolemia (FH) is a genetic disorder, an expression of defect in the gene that responsible for production LDL-C receptor. The current study was designed to determine FH patients city Sulaymaniyah both sexes. included 213 samples, number males 99 and females 114, sexes ranged from (30-79) years.The results cholesterol, triglyceride, high density lipoprotein (HDL-C), low-densi...

Purpose To evaluate lipids and C-reactive protein serum levels in patients with pseudoexfoliation syndrome (PEX) in the Polish population. Methods 96 patients were studied with PEX and 79 control subjects. Total cholesterol, triglycerides, high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol, non-HDL-cholesterol and CRP serum levels, and TG/HDL-C and TC/HDL-C ...

OBJECTIVE To investigate the relationship between inflammatory markers and atherogenic lipoprotein subfractions. METHODS We studied 520 eligible subjects who were not receiving any lipid-lowering therapy. The inflammatory markers including white blood cell (WBC) count, high-sensitivity C-reactive protein (hs-CRP), fibrinogen, erythrocyte sedimentation rate (ESR), and D-dimer were measured. A ...

 Anacetrapib (Merck & Co., Inc.) is a cholesteryl ester transfer protein (CETP) inhibitor that blocks the transfer of cholesterol from high-density lipoprotein to other lipoproteins. This results in an increase in high-density lipoprotein cholesterol (HDL-C) and a decrease in low-density lipoprotein cholesterol (LDL-C), which may reduce the development of atherosclerosis. Anacetrapib has not b...

When cultured human fibroblasts were incubated with medium of varying composition, the activity of the low density lipoprotein (LDL) receptor was strongly correlated with the amount of cholesterol that egressed from the cell. Particles isolated from lipoprotein-deficient serum (d > 1.25) by anti-apoprotein (apo) A-I affinity chromatography were as effective as the d > 1.25 serum in activating t...

Background: Dyslipidemia is a lipid metabolism disorder that causes changes in plasma lipoprotein function and/or levels of Triglycerides (TG), total cholesterol (TC), Low-Density Lipoprotein (LDL), and High-Density (HDL). Administration Medium Chain Triglyceride (MCT) non-pharmacological therapy effectively improves profiles reduces the risk dyslipidemia. Objectives: This study aimed to conduc...

aim: aim of present study was to review the effect of eight weeks aerobic training on visfatin total cholesterol and high density lipoprotein of middle age females. materials and methods: for these purpose 30 females (mean age 48/73±9/44 y, height 156/03±5/6 cm and weight 68/37±10/57 kg) who attend in odd day’s morning sport class of hejab gymnasium of shiraz city after fill health and informed...