نتایج جستجو برای: hexb
تعداد نتایج: 98 فیلتر نتایج به سال:
The first two steps of aflatoxin biosynthesis are catalyzed by the HexA/B and by the Pks protein. The phylogenetic analysis clearly distinguished fungal HexA/B from FAS subunits and from other homologous proteins. The phylogenetic trees of the HexA and HexB set of proteins share the same clustering. Proteins involved in the synthesis of fatty acids or in the aflatoxin or sterigmatocystin biosyn...
Many experimental studies, over the past two decades, have constantly reported a critical behavior for the transition from the smectic- A phase of liquid crystals to the hexatic- B phase with non- XY critical exponents. However, according to symmetry arguments this transition must belong to the XY universality class. Using an optimized Monte Carlo simulation technique based on the multihistogra...
Synthesis of directly linked diazine isosteres of pyrrole-polyamide that photochemically cleave DNA.
A distamycin model containing an isosteric diazine linked pyrrole has been designed and synthesized. The key steps of the synthesis involved the successful diazotization of the 4-amino-pyrrole derivatives to give the diazomium salts, which undergo coupling reactions with N-methylpyrrole to yield the directly linked diazine compounds. The amide isosteric-diazine pyrrole I demonstrated photo-indu...
Highly purified N-acetyl-beta-D-hexosaminidase B from normal urine and urine of a patient with mucolipidosis III was used to determine whether it has undergone any of the alterations associated with this genetic defect. Examination by sodium dodecyl sulphate/polyacrylamide gel electrophoresis showed that both the enzyme preparations contained protein components with apparent Mr values of 55 000...
NKT cells represent a distinct lineage of T cells that coexpress a conserved alphabeta T cell receptor (TCR) and natural killer (NK) receptors. Although the TCR of NKT cells is characteristically autoreactive to CD1d, a lipid-presenting molecule, endogenous ligands for these cells have not been identified. We show that a lysosomal glycosphingolipid of previously unknown function, isoglobotrihex...
Purpose: The aim of this study is to evaluate the diagnosis characteristics, clinic findings, phenotypical and genotypical features children with GM2 gangliosidoses.
 Materials Methods: file records 14 patients diagnosed gangliosidoses in our were retrospectively reviewed. was confirmed by determining levels serum total hexosaminidase β-hexosaminidase activity genetic analysis. 
 Resu...
Dupilumab, a monoclonal antibody that targets IL-4Ra, has shown significant clinical benefits in modulation of type 2(T2) inflammation atopic dermatitis(AD). To date, there are no detailed proteomic studies longitudinal changes AD skin proteins patients treated with dupilumab. Assessments lesional and non-lesional 20 during 16 weeks dupilumab treatment were done by tape stripping(STS) compared ...
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