At least four out of 97 low birth weight (less than 1750 g) newborn infants who had received only limited skin disinfection with 3% hexachlorophane (HCP) emulsion developed spongioform myelinopathy in association with detectable amounts of HCP in their brains. These four cases were found in a post-mortem survey of 20 out of the 27 infants who died. Another nine of these infants had detectable a...

This controlled double-blind study examined the efficacy of a single large inoculum of Staphylococcus aureus 502A in interrupting intrafamilial spread of recurrent staphylococcal abscesses. Forty families were enrolled in the study and 32 completed six months of follow-up care. All participants were first treated with oral oxacillin sodium or dicloxacillin sodium, twice daily hexachlorophene sh...

An evaluation of the relative effectiveness of 2% hexachlorophane and 0.75% Irgasan DP 300 bar soaps in disinfection of the hands showed that the former caused a significantly larger reduction in natural skin bacteria than the latter after one handwash and after six handwashings, three on each of two successive days. Repeated use of Irgasan DP 300 bar soap caused a significantly greater reducti...

In a field trial of three disinfectant-detergent preparations for the surgical scrub Hibiscrub (a 4% chlorhexidine detergent solution) maintained a significantly greater residual antibacterial action on the skin of the gloved hands of an operating team than was obtained with Disadine (povidone-iodine detergent preparation) (P<0.001). In comparison with Phisohex (3% hexachlorophane in detergent ...

The use of antiseptic treatment during cord care varies from unit to unit. Although it may reduce bacterial colonisation it may also delay cord separation. Where antiseptic treatment is used there is uncertainty as to the best agent. Hexachlorophane powder (0.3%) and 4% chlorhexidene detergent were each compared with dry cord care as a control on a two ward maternity unit in a six month open st...

Methicillin resistant Staph Aureus (MRSA) were studied in a 300 bedded Central Government Hospital Rawalpindi, in which 291 staff members were screened by nasal swabbing. Of 125 cases carrying staph aureus 5 (1.78%) were methicillin resistant. They were treated with Bacitracin ointment to be applied to interior nares four times a day for one week. Hexachlorophane baths daily, chlorhexidine sham...

BACKGROUND HIV-infected persons have increased risk of MRSA colonization and skin and soft-tissue infections (SSTI). However, no large clinical trial has examined the utility of decolonization procedures in reducing MRSA colonization or infection among community-dwelling HIV-infected persons. METHODS 550 HIV-infected adults at four geographically diverse US military HIV clinics were prospecti...

An outbreak of community-associated methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infection (SSTI) occurred in a college football team from August to September 2003. Eleven case-players were identified, and boils were the most common sign. Linemen had the highest attack rate (18%). Among 99 (93% of team) players with cultured specimens, 8 (8%) had positive MRSA nasal c...

Behavioral end points are being used with greater frequency in neurotoxicology to detect and characterize the adverse effects of chemicals on the nervous system. Behavioral measures are particularly important for neurotoxicity risk assessment since many known neurotoxicants do not result in neuropathology. The chlorinated hydrocarbon class consists of a wide variety of chemicals including polyc...