The mol-ecule of the title heterocyclic compound, C(16)H(17)N(3)O(3)S, is bent at the S atom with an C-SO(2)-NH-C torsion angle of 80.17 (8)°. The phenyl substituent at the S atom is rotated out of the plane of the 1H-indazole ring [inter-planar angle = 46.24 (8)°]. In the crystal, inter-molecular N-H⋯N and N-H⋯O hydrogen bonds build up a ribbon developing parallel to the b-axis direction. C-H⋯...

Heterocyclic compounds containing nitrogen are promising structure moiety for drug design. Dihydropyrimidines are one of the important heterocyclic compounds, which are of interest due to its efficiency towards various pharmacological uses. These are large group of structurally diverse compounds which are known to possess some characteristic properties like manifestations of novel structures, t...

Heterocyclic compounds are widely prevalent in animal kingdom as well as in plant kingdom and they play various roles in metabolic processes. A large number of heterocyclic compounds are in clinical practice as a drug, while many of them find industrial utility and hence the syntheses of heterocyclic compounds and understanding of the biological importance of specific heterocyclic class will be...

Selenium-containing heterocyclic compounds have been well recognized, not only because of their remarkable reactivities and chemical properties, but also because of their diverse pharmaceutical applications. In this context, isoselenocyanates have been emerged as a powerful tool for the synthesis of selenium-containing heterocycles, since they are easy to prepare and store and are safe to handl...

The five membered heterocyclic compounds pyrazolines were found as the core structure in a large variety of compounds. Pyrazoles have been the recent target of numerous methodologies, mostly due to their prevalence as scaffolds in synthesis of bioactive compounds and reactions in different media. In this review, an attempt is made to provide an up to date developments in the synthetic strategie...

The intramolecular [3+2] cycloaddition (32CA) of alkene-tethered α-silyloxydiazoalkanes provides variable stereoselectivity in generating bicyclic pyrazolines where the silyloxy group is either syn or anti to the newly formed pyrazoline ring. To elucidate the origin of the stereoselectivity, density functional theory (DFT) calculations were carried out for the energy of each transition state st...

Ammoxidation of technical lignins under mild conditions is a suitable approach to artificial humic substances. However, carbohydrates as common minor constituents of technical lignins have been demonstrated to be a potential source of N-heterocyclic ecotoxic compounds. Ethyl acetate extracts of ammoxidation mixtures of the monosaccharides glucose and xylose exhibited considerable growth inhibit...

Present communication deals with the synthesis and characterization of various spiro thiazolinone heterocyclic compounds. 4-(4-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylsulfonyl)phenyl)-1-thia-4-azaspiro[4.5]decan-3-one (5) was synthesized by facile and fast heterocyclization reaction, which further underwent condensation with 4-chlorobenzaldehyde to afford 2-(4-chlorobenzylidene)-4-(4-(6,7-dihy...

Flavonoids comprise a large family of plant derived polyphenolic compounds classified as flavonols, chalcones, aurones, flavanones, isoflavones, flavans, flavanonols, flavanols, and flavones differencing from each other in their structural group arrangements [1]. α,β-Unsaturated ketones display a wide range of pharmacological properties, including cytotoxicity towards different cancer cell line...