As part of natural products or biologically active compounds, the synthesis nitrogen-containing heterocycles is becoming incredibly valuable. Palladium a transition metal that widely utilized as catalyst to facilitate carbon-carbon and carbon-heteroatom coupling; it used in various heterocycles. This review includes twelve years successful indole using palladium catalysts establish carbon-nitro...

A series of morpholine substituted amino acids (phenylalanine, leucine, lysine and glutamic acid) was synthesized. A fragment-based screening approach was then used to evaluate a series of small heterocycles, including morpholine, oxazoline, dihydro-1,3-oxazine, tetrahydro-1,3-oxazepine, thiazoline, tetrahydro-1,3-pyrimidine, tetrahydro-1,3-diazepine and hexahydro-1H-benzimidazole, as potential...

Interest in saturated N-heterocycles as scaffolds for the synthesis of bioactive molecules is increasing. Reliable and predictable synthetic methods for the preparation of these compounds, especially medium-sized rings, are limited. We describe the development of SnAP (Sn amino protocol) reagents for the transformation of aldehydes into seven-, eight- and nine-membered saturated N-heterocycles....

The enantioselective synthesis of nitrogen-containing heterocycles (N-heterocycles) represents a substantial chemical research effort and resonates across numerous disciplines, including the total synthesis of natural products and medicinal chemistry. In this Article, we describe the highly enantioselective palladium-catalysed decarboxylative allylic alkylation of readily available lactams to f...

Three complexes of the general formula [Ru(TPA)L2](PF6)2 [TPA = tris(2-pyridylmethyl)amine], where L = pyridine (1), nicotinamide (2), and imidazole (3), were prepared and characterized spectroscopically. X-ray crystallographic data were obtained for 1 and 3. Complexes 1-3 show strong absorption in the visible region and selective release of heterocycles upon irradiation with visible light. Tim...

Abstract This thesis is concerned with the synthesis of -sultams and the development of new routes for the synthesis of bicyclic versions of these molecules as potential anti-bacterials. The synthesis of 1-azetines, 1,2-thiazetin-1,1-dioxides and isothiazol-1,1-dioxides as precursors of bicyclic heterocycles is described. 1-Azetines were synthesised from azetidin-2-ones prepared via the [2+2] c...

Nitrogen-containing heterocycles are important scaffolds for a large number of compounds with biological, pharmaceutical, industrial and optoelectronic applications. A wide range different methodologies the preparation N-heterocycles based on metal-catalyzed cyclization suitable substrates. Due to growing interest in Green Chemistry criteria over past two decades, use supported metal catalysts ...

transforming relatively complex starting materials into substituted heterocycles, and for the functionalization of existing heterocycles, there is less precedent for methodology which involves the direct, regiodefined synthesis of highly substituted heterocycles from simple starting materials. As such, new methods for the synthesis of substituted heterocycles (or their precursors) are potential...

The induction of benoxaprofen (BNX) glucuronidation in rats by intragastric administration of three nitrogen heterocycles (quinoline, 2,2'-dipyridyl, or 1,7-phenanthroline at 75 mg/kg daily for 3 days) has been investigated. BNX was administered i.v. at a dose of 20 mg/kg to bile-cannulated rats that had been induced. Blood and bile were collected over 8 h. Liver tissues were also collected at ...

Nitrogen heterocycles represent vital structural motifs in biologically-active natural products and pharmaceuticals. As a result, the development of new, convenient and more efficient processes to N-heterocycles is of great interest to synthetic chemists. Samarium(II) iodide (SmI₂, Kagan's reagent) has been widely used to forge challenging C-C bonds through reductive coupling reactions. Histori...