Acanthamoeba keratitis is a type of protozoa keratitis caused by free-living fresh water Amoeba. It recently gains importance because of increasing incidence, difficulty in diagnosis and unsatisfactory treatment. It is seen more commonly in contact lens wear using homemade saline or may be in non-contact lens wearers due to swimming or bathing in contaminated water. This infection is commonly c...

A causal role of herpes simplex infection in persistent epithelial defect following penetrating keratoplasty (PKP) has been documented in the past. Instead, not much information is available on the role of adenovirus infection in delayed epithelization following PKP. Here, we describe a case of persistent epithelial defect due to adenoviral infection keratitis confirmed by PCR analysis. Adenovi...

Nongenital herpes simplex virus type 1 is a common infection usually transmitted during childhood via nonsexual contact. Most of these infections involve the oral mucosa or lips (herpes labialis). The diagnosis of an infection with herpes simplex virus type 1 is usually made by the appearance of the lesions (grouped vesicles or ulcers on an erythematous base) and patient history. However, if un...

OBJECTIVE To report recurrent herpetic keratouveitis following YAG laser peripheral iridotomy. METHODS Case report. RESULTS A 64-year-old woman with a history of dendritic keratitis underwent Nd:YAG laser peripheral iridotomy and developed geographic epithelial keratitis with stromal keratouveitis. Culture of a corneal swab grew herpes simplex virus type I. Keratouveitis subsided with acycl...

The chronic keratitis resulting from the steroid treatment of acute herpes simplex infection of the rabbit cornea was significantly improved by the subconfunctival administration of either human or rabbit gamma globulin, the latter possessing no neutralizing antibody to herpes simplex virus. Virus titrations of this late lesion were consistently negative. The etiological and therapeutic implica...

Pretreatment of human fibroblast cultures with human leukocyte interferon (HIF, 1,000 IU/ml) resulted in a 24-h delay of virus replication after infection with vaccinia virus and herpes simplex virus type 1 and type 2. Additional HIF treatment 24 h after infection effectively lowered the maximum yield of viral infectivity. Equal results were obtained in simian cells with 3,000 IU of HIF per ml....