BACKGROUND Hereditary angioedema due to C1 inhibitor deficiency is characterized by recurrent acute attacks of swelling that can be painful and sometimes life-threatening. METHODS We conducted two randomized trials to evaluate nanofiltered C1 inhibitor concentrate in the management of hereditary angioedema. The first study compared nanofiltered C1 inhibitor concentrate with placebo for treatm...

n engl j med 364;1 nejm.org january 6, 2011 86 replacement therapy in patients with severe hereditary angioedema refractory to danazol prophylaxis. Transfusion 2009;49: 1987-95. 2. Bowen T, Cicardi M, Farkas H, Bork K, et al. 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema. Allergy Asthma Clin Immunol 2010;6:24. 3. Longhurst HJ, Farkas H...

Hereditary angioedema is an unusual condition that has been associated with a high mortality rate during acute attacks. The disease is felt to have a benign course in pregnancy, but some reports indicate a worsening of attacks in pregnant women. A case of a pregnant woman with known hereditary angioedema presenting with lifethreatening laryngeal oedema is reported, and is followed by a discussi...

Angioedema is an asymmetric non-pitting oedema on face, lips, tongue and mucous membranes; any delay in diagnosis and treatment can be fatal. Treatment with lisinopril as an angiotensin converting enzyme (ACE) inhibitor, can be a reason of angioedema. Here we report a case who developed oral-facial edema four years after using lisinopril/hydrochlorothiazide. Laryngeal oedema is a main cause of ...