نتایج جستجو برای: her2 gene
تعداد نتایج: 1152029 فیلتر نتایج به سال:
AIM To investigate human epidermal growth factor receptor type 2 (HER2) protein expression and gene amplification in Chinese metastatic prostate cancer patients and their potential value as prognostic factors. METHODS Immunohistochemistry (IHC) was performed to investigate HER2 protein expression in prostate biopsy specimens from 104 Chinese metastatic prostate cancer patients. After 3-11 mon...
HER2 overexpression has been observed in 20-30% of breast cancer cases. In addition to main products of HER2 gene, there are other variations, of which, the most important one is Δ16HER2. In principle, although HER2 overexpression is the first step for carcinogenesis, it is not sufficient, and the main reason responsible for breast tumorigenesis is Δ16HER2. This onco-protein, which lacks exon 1...
PURPOSE To analyze HER2 status in primary breast cancer (PBC) compared with correspondent metachronous metastases and to investigate whether BC phenotype may be predictive of change in HER2 expression. EXPERIMENTAL DESIGN HER2 was investigated by immunohistochemistry, silver in situ hybridization (SISH), and FISH, in a series of 137 tumors, building up a tissue microarray to concurrently anal...
Overproduction of the Her2 oncoprotein has been found in approximately 30% of breast tumors, and patients who have Her2 excesses typically have more aggressive disease. Here we show that the expression of the Her2 gene can be decreased by inhibiting the interaction of the two cancer-linked proteins, DRIP130/CRSP130/Sur-2 (a Ras-linked subunit of human mediator complexes) and ESX (an epithelial-...
A chromosomal region that includes the gene encoding HER2, a receptor tyrosine kinase (RTK), is amplified in 20% of breast cancers. Although these tumors tend to respond to drugs directed against HER2, they frequently become resistant and resume their malignant progression. Gene amplification in double minutes (DMs), which are extrachromosomal entities whose number can be dynamically regulated,...
The NCCN HER2 Testing in Breast Cancer Task Force was convened to critically evaluate the ability of the level of HER2 expression or gene amplification in breast cancer tumors to serve as a prognostic and a predictive factor in the metastatic and adjuvant settings, to assess the reliability of the methods of measuring HER2 expression or gene amplification in the laboratory, and to make recommen...
AIM Amplification of the Her2/neu gene and overexpression of the Her2/neu protein in gastric carcinoma (GC) is a golden criterion for target therapy with trastuzumab (Herceptin). We aim to evaluate the immunohistochemical protein expression and amplification of the oncogene Her2/neu by FISH technique in the epithelial gastric carcinoma and to compare their association with different clinicopath...
OBJECTIVE To detect expression of HER2 and SATB1 in paraffin tissues of gastric cancer, and to investigate their relationship with clinic pathological factors and prognosis, and further analyze the correlation between the expression of SATB1 and HER2. PATIENTS AND METHODS RT-PCR was used to determine the expression of SATB1 gene and immunohistochemistry (IHC) was used to detect the expression...
background: trastuzumab (herceptin) is a humanized monoclonal antibody (mab) which is used for specific treatment of metastatic breast cancer in patients with overexpression of her2/neu receptor. in this study, we have attempted to develop a biosimilar version of trastuzumab mab. methods: according to in silico studies, the heavy and light chains of trastuzumab mab were designed and constructed...
PURPOSE/OBJECTIVES To review the clinical significance, methods of testing, and outcomes of trastuzumab (Herceptin) treatment for HER2 gene amplification and HER2 protein overexpression in breast cancer. DATA SOURCES Published articles and abstracts, online resources, a clinical handbook, and product information. DATA SYNTHESIS HER2 gene amplification or HER2 protein overexpression can be f...
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