A novel compound, ethyl 7-methyl-1-(4-nitrophenyl)-5-phenyl-3-(thiophen-2-yl)-1,5dihydro[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylate (7) was synthesized by reaction of N-(4nitrophenyl)thiophene-2-carbohydrazonoyl chloride (1) with ethyl 6-methyl-4-phenyl-2-thioxo1,2,3,4-tetrahydropyrimidine-5-carboxylate (2). The mechanism of the studied reaction is discussed and the assigned structure was co...

In our study, we aimed to synthesize novel grafted hyaluronic acid with cationic biodegradable polymer, poly (N-vinyl imidazole) (PVI), through free radical polymerization using potassium persulfate as initiator. The effect of various grafting factors including initiator and monomer concentrations, reaction time and temperature was studied on the percentage of grafting parameters such as; graft...

Chemotherapy and immunotherapy are the main remedies used in cancer treatment. Because immunotherapy can not only reduce the toxicity of chemotherapeutics but also enhance antitumor effects in vivo, combining these two therapies is a trend that continues to gain more attention in clinic. SEP, a polysaccharide isolated from Strongylocentrotus nudus egg, has been reported to display antitumor act...

Three new lupane-triterpenoids (1-3) along with six known compounds (4-9) were isolated from the ethanolic extract of whole plant of Potentilla discolor Bunge. The structures of Compounds 1-3 were established by extensive 1D and 2D NMR together with other spectrum analysis, indicating that their C-27 positions were highly oxygenated, which were rarely found in nature. Their in vitro anti-prolif...

BACKGROUND The aim of this study was to investigate the effect of a c-myc antisense oligodeoxynucleotide and 5-fluorouracil on the expression of c-myc, invasion and proliferation of HEPG-2 liver cancer cells. MATERIALS AND METHODS HEPG-2 cells were treated with lipiosome-mediated c-myc ADSON and 5-fluorouracil. The proliferation inhibition rate and invasion were measured by MTT and invasion a...

A novel heteropolysaccharide from the fruiting bodies of Gomphus clavatus Gray was isolated through Sephadex G-200 and DEAE-cellulose columns. The Gomphus clavatus Gray polysaccharide (GCG-1) was mainly composed of β-D-glucosepyranose (β-D-Glu) and α-D-galactopyranose (α-D-Gal) in a ratio of 3:2 and had a molecular weight of ~50,000 Da. The structure of GCG-1 was investigated by a combination o...

In the present study, a set of 2-anilino-4-alkylaminoquinazoline derivatives were synthesized and tested for their antitumor activities in vitro against panel four human cancer cell lines DNA-binding affinity. Among compounds, 4c 5b with 4-substitution at phenyl ring found to have highest inhibitory effects breast adenocarcinoma (MCF-7), colon (HCT-116), hepatocellular carcinoma (HePG-2), skin ...

Aim: To compare the cytotoxic effect in vitro and antitumor effect in vivo of oridonin nanoliposomes injection(O-NL) and free oridonin solution(O-F). Methods The cytotoxic effect of O-NL and O-F against HePG-2 and MGC-803 cells in vitro were studied by MTT assay method. The antitumor effect studies in vivo of O-NL and O-F were performed in murine heptocarcinoma H22 tumor-bearing mice after iv a...