This paper investigates the role of CTL and antibody responses in hepatitis C virus (HCV) dynamics and pathology. Mathematical models suggest that a strong CTL response is required for resolution of HCV infection and that a weak CTL response can result in persistent infection. According to the model, establishment of persistent infection is accompanied mainly by an ongoing antibody response, wh...

Serum samples with lower temperature-dependent antibody with low avidity to C100-3 (HCV) antigen were found in 0.19% of 23,197 voluntary blood donors at this blood center. They showed positive C100-3 antibody activity at 24 C but not at 37 C. The antibody activity bound to C100-3 antigen at lower temperature disappeared after incubation for 60 min at 37 C or treatment with 8 M urea. Other marke...

background: hepatitis c is one of the most important etiological factor in chronic liver disease which could lead to the progressive liver cirrhosis and hepatocellular carcinoma. the purpose of this study is to determine the prevalence of hepatitis c in east of golestan province (north-east of iran). materials and methods: 2123 inhabitants from north-east of iran of general population have been...

conclusions we confirm that in amol city and surrounding areas, the prevalence of true hcv infection is 0.05%, which is lower than that previously reported from iran. results the mean age of participants was 42.70 ± 17.10 years. of these participants, 57.2% (n = 3483) were male. anti-hcv antibody was positive in 12 individuals from which five were riba positive. three of these subjects were pcr...

BACKGROUND Previous studies have shown that some viral infections may be triggers for autoimmune diseases. The role of viral infections in the etiopathogenesis of pemphigus has also been investigated. OBJECTIVES To investigate the relationship between pemphigus and the hepatitis B and C virus infections. METHODS This retrospective study included 62 patients with pemphigus and 50 healthy con...

Background & Aims: Hepatitis B virus is one of the causes of acute and chronic hepatitis. Due to multiple hospitalization and blood transfusion, thalassaemic patients are at higher risk of this infection. Duration of the immunity after vaccination in this high-risk group and the need for booster vaccination is uncertain. The aim of this study was to find antibody titration and immunity to Hepat...

UNLABELLED BACKGROUNDPURPOSE: Hepatitis C virus (HCV) is a major public health problem and can cause severe liver disease. The public has little understanding of hepatitis C. Therefore, a survey was performed to investigate the awareness of nonspecialists in China of hepatitis C. METHODS A questionnaire on hepatitis C was publicized on the medical community site DXY.cn from April 15 to July 1...