Vascular endothelial growth factor (VEGF) is crucial for vascular development in several organs. However, the specific contribution of epithelial-VEGF signaling in the liver has not been tested. We used a mouse model to specifically delete Vegf from the liver epithelial lineages during midgestational development and assessed the cell identities and architectures of epithelial and endothelial ti...

The global feeding on Western diet, which is enriched in fat and fructose, has been proposed to be a cause of metabolic disorder, including hepatic steatosis which is associated with oxidative stress. In the present study, we investigated the influence of co-treatment with phytochemical compounds, quercetin (Q), o-coumaric (CA) and berberine (BB) on the hepatic lipid profile and oxidative stres...

Tissues of bowhead, beluga, and gray whales were analyzed for Ag, Cd, Cu, Se, Zn, THg and MeHg (belugas only). Delta15N and delta13C in muscle were used to estimate trophic position and feeding habitat, respectively. Trace element concentrations in tissues were significantly different among whale species. Hepatic Ag was higher in belugas than bowheads and gray whales. Gray whales had lower Cd c...

in this study, cadmium (cd) accumulation was studied in an experimental aquatic exposure. mosquitofish (gambusia affinis) were acutely exposed for 96 h to a high concentration of cd (12 mg/l) and were chronically exposed to a low concentration of cd(0.4 mg/l) for 30 days. cd accumulation profiles differed between the two cd exposures. the cd concentation in g. affinis tissues increased linearly...

This study investigates the potential of green tea to modulate oxidative stress and angiotensin II AT(1) receptor expression in renal and hepatic tissues of diabetic rats. Three groups of rats were studied after 8 weeks following diabetes induction: normal, streptozotocin-induced diabetic (diabetic control), and green-tea-treated diabetic rats. Total antioxidant, catalase, and malondialdehyde l...

Psoralea corylifolia L. (PC) is a traditional Chinese herb used to treat yang deficiency of the spleen and kidney in pediatric disease. Recent studies have shown its liver protection and anti-oxidative effects. The aim of this study was to explore the effect and mechanism of PC on nonalcoholic steatohepatitis in juvenile mice. The juvenile mouse model of nonalcoholic fatty liver disease/nonalco...

although gastrointestinal bleeding is common, hemobilia due to the rupture of hepatic artery pseudoaneurysm is uncommon. we report a case of hemobilia which was successfully treated via angiography.

One of the most common public liver diseases over world is fatty which contain alcoholic and non-alcoholic liver. One-fourth among general population are impact Non-Alcoholic Fatty Liver Disease (NAFLD) in worldwide.Retinol binding protein 4 (RBP4) known as an adipokine, mainly synthesized secreted from form adipose tissues. RBP4 acts a transporter specifically bound to retinol others Visfatin ...

The goal of the current paper is to explore the role of liver biopsy as a tool in detection of hepatic oxidative stress, with brief notes on different types of free radicals, antioxidants, hepatic and blood oxidative stress, and lipid peroxidation. Hepatic oxidative stress was investigated for many years in human and animals, but most of the studies performed in animals were concerned with stud...

Aim: Background: Voluminous of the anti-tumor drugs in practice known to yield adverse side effects for instance hepatotoxicity. Objective: This preliminary was carried out ascertain histological change after treatment with Sorafenib (SOR) before execution B17 coadministration and detection histochemical Ascites Carcinoma mice model (EAC). Methods: In total 12 Swiss albino received intraperiton...