Bleeding is the major complication of anticoagulant therapy. The criteria for defining the severity of bleeding varied considerably between studies, accounting in part for the variation in the rates of bleeding reported. Since the last review, there have been several meta-analyses published on the rates of major bleeding in trials of anticoagulants for atrial fibrillation and ischemic heart dis...

To the Editor: Thrombosis associated with severe thrombocytopenia is an infrequent, but life-threatening side effect of heparin therapy, which can involve any venous or arterial territory including the cerebral circulation. The treatment of this serious complication has not been satisfactorily resolved. Recently, Becker and Miller reviewed heparin-induced thrombocytopenia with thromboembolism a...

Abstract Background Endoscopic removal of colorectal adenoma is considered an effective treatment for reducing the mortality rates associated with cancer. Warfarin, a type anticoagulant, widely used and prevention thromboembolism; however, bleeding may increase its administration after polypectomy. In recent times, high incidence endoscopic polypectomy has been reported in patients receiving he...

Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels. However, the safety and efficacy of heparin and insulin in the treatment of hypertriglyceridemia-associated acute pancreatitis have not been well established yet. We successfully used heparin and insulin as firs...

Heparin rebound phenomenon was named to illustrate unstable angina pectoris (UAP) reactivation after stopping heparin. Reinfarction clustering, as well as sharp increase of both thrombin production and activity in the early hours after heparin abandoning have been described (after thrombolysis), which has been partially attributed to heparin rebound. The aim of the study was to show importance ...

Heparin is frequently used in different clinical settings to reduce the coagulating ability of the blood. Because of probable adverse effects owing to heparin therapy and regarding variability of patients' responses to heparin, which make it very unreliable, it seems prudent to monitor meticulously its effects on the human body. There are a lot of laboratory tests to watch its effects on the bo...

We describe a case of 70 years old female patient in whom an initial diagnosis acute coronary syndrome (ACS) revealed to be finally aortic dissection. This report emphasizes the importance maintain high grade suspicion dissection as possible alternative presence electrocardiographic myocardial ischemic changes. In many medical centers where thrombolytic therapy, antiplatelet receptor blockers, ...

A study of blood coagulation was made on cardiac patients with and without acute myocardial infarction, prior to anticoagulant therapy. The heparin clotting time, an in vitro modification of the heparin tolerance test, was accelerated in 74 per cent (14 out of 19) of the patients with acute myocardial infarction studied within three weeks after the attack. One out of 14 patients without acute m...

The Seventh American College of Chest Physicians (ACCP) Conference on Antithrombotic and Thrombolytic Therapy provides guidelines for outpatient management of anticoagulation therapy. The ACCP guidelines recommend short-term warfarin therapy, with the goal of maintaining an International Normalized Ratio (INR) of 2.5 +/- 0.5, after major orthopedic surgery. Therapy for venous thromboembolism in...

OBJECTIVE Secondary brain injury leads to high morbidity and mortality rates in patients with aneurysmal subarachnoid hemorrhage (aSAH). However, evidence-based treatment strategies are sparse. Since heparin has various effects on neuroinflammation, microthromboembolism and vasomotor function, our objective was to determine whether heparin can be used as a multitarget prophylactic agent to amel...