Dr. J.-C. Davin, Service de Pédiatrie, Bât. 35, CHU Sart-Tilman, B-4000 Liège 1 (Belgium) Dear Sir, In 1988, we demonstrated an increased intestinal permeability to [51Cr]EDTA in some children presenting with idiopathic IgA nephropathy or with Henoch-Schönlein purpura nephritis [1]. Three further studies of intestinal permeability were reported in adult idiopathic IgA nephropathy [2-4]. Two [2,...

We describe a 17-year-old male who presented with thrombotic thrombocytopenic purpura (TTP) and 2 years thereafter developed central nervous system lupus and nephritis. The association of TTP and systemic lupus erythematosus has been described, but the unusual sequence and chronological separation is very rare.

BACKGROUND The most appropriate management of Henoch-Schönlein Purpura (HSP) nephritis with nephrotic-range proteinuria remains uncertain. The aim of this study was to evaluate the clinical therapeutic effects of mycophenolate mofetil and low-dose steroid in Henoch-Schönlein purpura nephritis (HSPN) with nephrotic-range proteinuria and pathological classification less than IV in children. MATER...

INTRODUCTION Henoch-Schönlein purpura is a systemic disease with frequent renal involvement, characterized by IgA mesangial deposits. Streptococcal infection can induce an abnormal IgA immune response like Henoch-Schönlein purpura, quite similar to typical acute post-infectious glomerulonephritis. Indeed, hypocomplementemia that is typical of acute glomerulonephritis has also been described in ...

Henoch-Schönlein purpura (HSP) is the most common vasculitis in children, mainly affecting the small vessels of the skin, joints, gastrointestinal tract, and kidneys. Although most cases of HSP resolve spontaneously without sequelae, serious nephrological and intestinal problems may occur in some cases. We experienced a case of HSP complicated by simultaneous intussusception and nephritis in a ...

Henoch-Schönlein purpura is one of the most common causes of systemic vasculitis. Henoch–Schönlein purpura typically affects children between the age of 3 and 10 years. The aetiology is unknown. Diagnosis includes palpable purpura (essential) in the presence of diffuse abdominal pain, acute arthritis/arthralgia, renal involvement characterized by haematuria and/or proteinuria (Ozen et al., 2006...

Methods Twenty-four patients (16 female) with pSLE nephritis (44 serum samples, 22 in active nephritis) and 21 patients (18 female) with pSLE without nephritis (32 serum samples, 19 in active pSLE) were enrolled in the study. The disease control group included 17 patients with nephritis of other causality (Henoch-Schönlein purpura nephritis, IgA nephropathy, postinfectious glomerulonephritis, m...

Henoch-Schonlein Purpura (HSP) is the commonest vasculitis in children, and outcome depends on renal involvement or occurrence of HSP nephritis (HSPN). Hence, a meticulous diagnosis, treatment regular follow-up plan needed for better prognosis. A case 12 - year old girl showing HSPN symptoms only eight weeks after first onset reported. Symptoms might appear later, hence emphasising importance c...

11.1: Treatment of HSP nephritis in children 11.1.1: We suggest that children with HSP nephritis and persistent proteinuria, 40.5-1 g/d per 1.73 m, are treated with ACE-I or ARBs. (2D) 11.1.2: We suggest that children with persistent proteinuria, 41 g/d per 1.73 m, after a trial of ACE-I or ARBs, and GFR 450 ml/min per 1.73 m, be treated the same as for IgAN with a 6-month course of corticoster...