접수 : 2007년 8월 23일, 승인 : 2007년 9월 13일 책임저자: 박혜원, 포천중문의대 소아과학교실 Correspondence: Hye Won Park, M.D. Tel : 031)780-5230 Fax : 031)780-5239 E-mail : [email protected] 하 등을 특징으로 하는 드문 질환으로 영아나 어린 소아의 급성 신부전의 가장 흔한 원인이다 1, 2) . 미세혈관병증 용혈성 빈혈의 성상은 파편이 된 적혈구(schistocytes)가 말초혈액 도말 검사에 서 관찰되고 혈청 lactate dehydrogenase(LDH), 유리 혈색소와 망상 적혈구가 증가하며, 대개의 경우 혈소판 수치는 60,000/ mm 3 이하로 감소한다 1, 3) . 임상 증상과 예후...

Hemolytic uremic syndrome (HUS) is defined by the triad of mechanical hemolytic anemia, thrombocytopenia and renal impairment. Atypical HUS (aHUS) defines non Shiga-toxin-HUS and even if some authors include secondary aHUS due to Streptococcus pneumoniae or other causes, aHUS designates a primary disease due to a disorder in complement alternative pathway regulation. Atypical HUS represents 5 -...

HUS is one of the most common causes of acute renal failure in childhood. D+ HUS is the most common form and usually follows an episode of hemorrhagic colitis due to VTEC or S. dysenteriae type 1. The SLT elaborated by these organisms is responsible for the endothelial damage that is the initial insult in the pathogenesis of the acute renal failure. Excellent supportive care is necessary to red...

Introduction Early diagnosis of atypical uremic-hemolytic syndrome may be challenging during the puerperium period. Correct diagnosis and timely management are crucial to improve outcomes. Background Pregnancy-associated atypical hemolytic-uremic syndrome (p-aHUS) is a rare condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. Triggered by preg...

The hemolytic-uremic syndrome (HUS) has been recognized for more than 45 years and consists of the combination of hemolytic anemia, thrombocytopenia, and acute renal failure. HUS occurs predominantly in children younger than 4 years of age. It is the most frequent cause of acute renal failure in children. The most common form of the syndrome (D+ HUS) occurs in healthy young children (>6 mo to <...

In1955 Gaser et al first reported Hemolytic uremic syndrome (HUS) in children who showed microangiopathic haemolytic anemia, thrombocytopenia, and acute renal failure [1]. HUS, recognised for more than 55 years, is one of the most common causes of acute renal failure in children [2]. It consists of the triad of microangiopathic haemolytic anemia, thrombocytopenia, and acute renal failure. The s...