Hemolytic transfusion reactions represent one of the most common causes of transfusion-related mortality. Although many factors influence hemolytic transfusion reactions, complement activation represents one of the most common features associated with fatality. In this paper we will focus on the role of complement in initiating and regulating hemolytic transfusion reactions and will discuss pot...

BACKGROUND In recent years, pulmonary transfusion reactions have gained increasing importance as serious adverse transfusion events. METHODS Review of the literature. RESULTS Pulmonary transfusion reactions are not extremely rare and, according to hemovigilance data, important causes of transfusion-induced major morbidity and death. They can be classified as primary with predominant pulmona...

BACKGROUND In vitro studies suggest that mediators of systemic inflammatory response syndrome are generated in the course of hemolytic transfusion reactions. Evidence for the in vivo significance of these findings is given by the present clinical and laboratory analysis of a severe delayed hemolytic transfusion reaction (DHTR). CASE REPORT A 67-year-old patient (blood group O, D-negative) wit...

The Rhesus (Rh) blood group system is one of the most complex systems. Over 46 different antigens have been serologically defined. Rh antigens are associated with the red cell membrane and are considered important fortheir integrity. The genes for Rh antigens are encoded together on the short arm of chromosome. One gene codes for Rh D antigen while the other gene encodes the polypeptide carryin...

BACKGROUND Patients with malignancy comprise a unique group for whom transfusions play an important role. Because the need for transfusions may span a long period of time, these patients may be at risk for more adverse events due to transfusion than other patient groups. METHODS A literature search on PubMed that included original studies and reviews was performed. The results were summarized...

BACKGROUND Hyperhemolytic Syndrome or Hyperhemolytic Transfusion Reaction (HHTR), a life-threatening subset of Delayed Hemolytic Transfusion Reaction (DHTR) is characterized by destruction of both transfused and autologous erythrocytes evidenced by a fall in post transfusion hemoglobin below the pre-transfusion level. CASE REPORT We describe a case of DHTR due to anti-P1 alloimmunization mani...

BACKGROUND Non-ABO alloantibodies are frequently implicated in hemolytic transfusion reactions and are a leading cause of transfusion-related mortality. Detection of clinically significant non-ABO alloantibodies is reliant on an antibody screen, which is prone to clerical, technical, and reagent error. Data on the frequency of false-negative antibody screens due to the occurrence of these error...

Pre-transfusion testing is performed to ensure the normal survival of transfused red blood cell products i.e. to prevent hemolytic transfusion reaction via immune-mediated mechanism [1]. The serological part of pre-transfusion testing includes; ABO group and Rh (D) type, antibody screening and crossmatching [2]. Antibody screening is included to detect unexpected antibody and was first introduc...