In the 1940s and the 1950s, severe neonatal hyperbilirubinemia and kernicterus were most often encountered with hemolytic disease of newborn (HDN), which occurs most often as a result of the incompatibilities of the Rh and ABO blood groups. With the advent of prenatal testing, maternal Rh°(D) immunoglobulin, phototherapy, and exchange transfusion, the incidence of severe hyperbilirubinemia dras...

The development outcome of 16 infants who had rhesus disease was assessed at 18 months. Eight had received intravascular intrauterine transfusion and eight postnatal exchange transfusions. There was no difference in developmental outcome and neither group was different from the population as a whole.

Introduction: Hemolytic disease of the newborn is a clinical condition in which fetal red blood cells are destroyed by maternal allo-antibodies directed red blood cell antigens acquired from the father. Justification: In many developing countries like Zambia, the true incidence of Hemolytic Disease of the New Born is not known. It may be postulated that hyperbilirubineamia due to ABO incompatib...

KM The primary cause, of course, is maternal antibodies to red blood cells. Their formation usually occurs at delivery, and in the following pregnancy, those antibodies cross through the placenta and can affect the next fetus. When the antibodies attach to the fetal red blood cells, the cells break down and the fetus becomes anemic. In the United States, the 3 antibodies that cause nearly all t...

demomnstrated loiv conncenntrat.ionns of complement shortly after the occurrennce of hemobytic crises inn paroxysmal cold hemogbobinnuria. Young, et al.4 foumnd that the complement bevels of dogs dropped sharply aind rose fain-ly promptly to normal values after the production of intravascular hemobysis by the adminnistrationn of imncompatible blood transfusions. Dacie amid de Gruchy5 reported a...

Prior to the availability of anti-D immunoglobulin (anti-D Ig), the incidence of Rh(D) alloimmunisation in D negative women following two deliveries of D positive, ABO-compatible infants was approximately 16%, and haemolytic disease of the newborn (HDN) due to anti-D was a significant cause of morbidity and mortality. Following routine post-partum administration of anti-D Ig, the rate of alloim...