نتایج جستجو برای: hemoglobinuria
تعداد نتایج: 2365 فیلتر نتایج به سال:
B/J .JAMES A. Boxxix AND LAWRENCE SCHWARTZ S OME SEVENTY YEARS AGO, Ehrlich,’ in 1881, first described erythrophagocytosis in a case of paroxysmal hemoglobinuria. Since thets his observations of in vivo erythrophagocytosis in the peripheral blood have been confirmed and extended by numerous other investigators. Without attempting an exhaustive review of the literature, some of the conditions it...
Dark-colored urine is one of the clinical symptoms of envenomation by Micropechis ikaheka (New Guinea small-eyed snake). We have purified a phospholipase A(2), MiPLA-1, which induces dark-colored urine in experimental mice, to homogeneity. The analysis of the dark-colored urine by electrophoresis and N-terminal sequence determination indicated that the color of mouse urine is due to hemoglobin ...
Iptacopan (LNP023) is a first-in-class, oral, low molecular weight, Factor B inhibitor being developed for the treatment of diseases associated with activation alternative complement pathway. Current Phase III studies iptacopan include paroxysmal nocturnal hemoglobinuria, C3 glomerulonephritis, IgA nephropathy, and atypical hemolytic uremic syndrome. Preclinical identified CYP2C8, OATP P-gp as ...
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Intravascular hemolysis and hemoglobinuria are associated with sickle cell nephropathy. ApoL1 is involved in cell-free hemoglobin scavenging through association with haptoglobin-related protein. APOL1 G1/G2 variants are the strongest genetic predictors of kidney disease in the general African-American population. A single report associated APOL1 G1/G2 with sickle cell nephropathy. In 221 patien...
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