CLINICAL MANIFESTATIONS OF INHERITED ABNORMAL HEMOGLOBINS. I. THE / \. INTERACTION OF HEMOGLOBIN-S WITH HEMOGLOBIN-D. II. INTERACTION / OF HEMOGLOBIN-E AND THALASSEMIA TRAIT Phillip Sturgeon, Harvey A. Itano and William R. Bergren 389 STUDIES ON ABNORMAL HEMOGLOBINS. XI. SICKLE CELL-THALASSEMIA DISEASE IN THE NEGRO. THE SIGNIFICANCE OF THE S + A + F AND S -4A PATTERNS OBTAINED BY HEMOGLOBIN ANA...

BACKGROUND Vitamin D and iron deficiencies frequently co-exist. It is now appreciated that mechanistic interactions between iron and vitamin D metabolism may underlie these associations. OBJECTIVE We examined interrelations between iron and vitamin D status and their regulatory hormones in pregnant adolescents, who are a group at risk of both suboptimal vitamin D and suboptimal iron status. ...

During 1978-81 there were about 43,500 births in Birmingham, of which 10.3% were to Negroes and 22.6% to Asians. Cellulose acetate electrophoresis of red cell haemolysates from capillary specimens collected for phenylketonuria screening was performed for these babies to assess the feasibility, cost, and benefits of detecting sickle haemoglobinopathies early. Eight babies had important haemoglob...

To determine the influence of cell cycle-specific agents on primate hematopoiesis and fetal hemoglobin production, two juvenile cynomolgus monkeys (Macaca fascicularis) were repeatedly bled to maintain their hemoglobins at approximately 6.5 g/dl and fetal hemoglobin levels at 3-5%. Six separate 5-d courses of hydroxyurea at 100 mg/kg per d were then administered over the next 200 d while phlebo...

Hypoxic exposure results in physiological adaptions and enhanced human athletic performance. However, few reports exist regarding responses of horses to similar conditions. The goals this preliminary work were evaluate whether could be acclimated a hypoxic chamber (HC) monitor their Trial 1: Two 4-yr-old Thoroughbreds used establish protocols for adaptation the HC. Horses stalled HC 8 10 h/d wh...

1. The effect of in vitro glycation on delta-aminolevulinic dehydratase (ALA-D) under several experimental conditions was investigated. When preincubated with 500 mM glucose at 37 degrees C for 20 hr, ALA-D was 80% inactivated and glycated hemoglobin levels were increased more than fourfold. 2. Thiobarbituric acid species were not modified during glycation; therefore ALA-D inactivation cannot b...

Specific anti-(rabbit cathepsin D) serum, previously shown to inhibit cathepsin D, arrested the intracellular digestion of sheep IgG and radiochemically labeled hemoglobin and proteoglycan in rabbit alveolar macrophages. In the presence of antiserum, cells remained viable, but became very vacuolated. Both sheep IgG and hemoglobin were demonstrated immunocytochemically in vacuoles most of which ...

Chronic Kidney Disease (CKD) didefinisikan sebagai kerusakan ginjal dengan penurunan Glomerular Filtration Rate (GFR) kurang dari 60 ml/menit/1,73 m2 yang terjadi selama lebih tiga bulan. Penurunan fungsi dapat menyebabkan produksi hormon eritropoietin berfungsi untuk memproduksi sel darah berkurang sehingga kadar hemoglobin. Selain itu, aktivasi vitamin D penyerapan kalsium di usus berkurang. ...