A dominant mutation in the mouse, Hemimelia-extra toe (Hmx), induces congenital limb malformations in heterozygotes. Typical expression includes axial shortening of the radius, tibia and talus ('hemimelia'), with supernumerary metacarpals, metatarsals, and digits ('polydactyly'). Pathogenesis was investigated during developmental stages 16 through 22 (11th through 15th days of gestation). Full ...

we have previously observed that neonatal or adult splenectomy has no significant effect on the multiplication of Mycobacterium leprae in mice. Additionally, creating abnormal reaction to hind feet with a mixed infection with M. leprae and Corynebacterium kuscheri or by mixing oil (adjuvant such as Drakeol No. 6, liquid paraffin, or vegetable oil) with M. leprae caused either no growth or reduc...