Hematoporphryrin derivative at an intracellular concentration in TA-3 mouse mammary carcinoma cells of 0.6 or 0.9 mM required input of 3.0 X 3.6 X 10(9) quanta/cell of red light (620 nm) to achieve a 90% kill. At an intracellular concentration of 1.2 mM, this light requirement drops to 1.5 X 10(9)quanta/cell. The energy for this photodynamic process is about 100 times higher than that required ...

Experiments were performed to determine the effect of hematoporphyrin derivative (HPD) photodynamic therapy on blood flow to normal rat intestine. A segment of rat jejunum was exposed to red (greater than 590 nm) light (200 mW/cm2) 24 h after the i.v. administration of HPD. Blood flow to the light exposed segment was determined using the radioactive microsphere technique while blood flow to an ...

The photophysical characterization of an extended zinc porphyrin is reported. Fusion of bis-tetraazaanthracene on the porphyrin ring causes an unusual dual luminescence ascribed to two non-equilibrated singlet excited states.

A simple zinc porphyrin with an acrylic acid at the meso position exhibits an energy conversion efficiency of 5.1%, demonstrating its potential for cost-effective dye-sensitized solar cells.

Cells of the established line NHIK 3025 were incubated with hematoporphyrin derivative and exposed to light at different concentrations of oxygen. The efficiency of photoinactivation of the sensitized cells decreased with decreasing oxygen concentration. No photoinactivation was observed when the atmosphere above the medium overlying the cells was pure N2 gas. With 1% O2 in the atmosphere, the ...

Exponentially growing melanoma cells of the line FME were incubated with hematoporphyrin derivative (HpD) for 1 and 18 h and subsequently exposed to light in the presence of HpD. Quantitative changes in the expression of the melanoma-associated surface antigen p250 recognized by the monoclonal antibody 9.2.27 were studied by flow cytometry. Treatment with HpD and light resulted in no immediate ...

Aim: To evaluate the capacity of hematoporphyrin monomethyl ether 23 (HMME) in the presence of light to cause photodynamic inactivation (PDI) of C. 24 albicans. Materials & methods: HMME photoactivity was evaluated against 25 azole-susceptible and resistant C. albicans. The mechanisms by which PDI of C. 26 albicans occurred were also investigated. Results: HMME-mediated PACT caused a 27 dose-de...

Background Photodynamic therapy (PDT) is a promising new cancer treatment strategy which inactivates tumor cells by simultaneoulsy using light and a photosensitizer. The similarity between tumors and newly implanted embryos is notable. Extrauterine pregnancy (EUP) does not have a definite treatment and previous therapeutic options (medical and surgical) have not been effective or suitable. Ther...