Background and aimsHeterogeneous high-density lipoprotein (HDL) particles, which can contain hundreds of proteins, affect human health disease through dynamic molecular interactions with cell surface proteins. How HDL mediates its long-range signaling functions various types is largely unknown. Due to the complexity HDL, we hypothesize that multiple receptors engage particles resulting in condi...

High-density lipoprotein (HDL) functionality has been reported to be associated with coronary artery disease (CAD). However, little is known about the impact of HDL on atherosclerosis. Thirty-eight type 2 diabetic patients CAD who underwent percutaneous intervention were examined. Coronary atheroma burden and plaque composition culprit lesions assessed using conventional gray-scale integrated b...

A high resolution electrophoretic method has been developed to separate plasma high density lipoprotein (HDL) particles by size using 4-30% polyacrylamide agarose (PAA) gradient gels, Sudan black B staining, and laser densitometry. Fourteen distinct HDL bands were observed with HDL-1 being designated as the largest particle and HDL-14 as the smallest particle. HDL-1 was similar in size to ferri...

BACKGROUND A growing body of evidence from epidemiological data, animal studies, and clinical trials supports HDL as the next target to reduce residual cardiovascular risk in statin-treated, high-risk patients. For more than 3 decades, HDL cholesterol has been employed as the principal clinical measure of HDL and cardiovascular risk associated with low HDL-cholesterol concentrations. The physic...

Although tension-type headache (TTH) is the most common primary in world, much fewer studies on its pathophysiology have been carried out comparison to other headaches. Inflammatory processes are important of both peripheral and central pain. Studies role inflammatory markers TTH patients limited. Therefore, this study, it was aimed examine parameters TTH. 199 154 control participants were invo...

Particle size of low density (LDL) and high density (HDL) lipoproteins and cholesterol esterification rate in HDL plasma (FER(HDL)) are important independent predictors of coronary artery diseases (CAD). In this study we assessed the interrelations between these indicators and routinely examined plasma lipid parameters and plasma glucose concentrations. In 141 men, healthy volunteers, we examin...

It is a great irony that the earliest discovered lipoprotein is also the least well understood. In 1929, Michel Machebouef at the Pasteur Institute in Paris, using salt precipitation techniques, isolated a lipoprotein particle from horse serum composed predominantly of an a-globulin (59%), which we now know to be high-density lipoprotein (HDL) (1). Epidemiological studies in the 1970s, includin...

La variabilité intra-individuelle du cholestérol, et plus précisément LDL-cholestérol, mais, possiblement aussi, celle HDL-cholestérol apparaissent comme potentiellement délétères. Plusieurs études ont objectivé une association indépendante entre la d’une part, le risque d’accidents cardiovasculaires (infarctus myocarde, accident vasculaire cérébral) mortalité globale, d’autre part. Par ailleur...