BACKGROUND Fast reduction of serum free light chain (FLC) levels correlate with renal recovery in cast nephropathy. Because convection has the capacity to remove proteins of higher molecular weights, we hypothesized that haemodiafiltration (HDF) would be superior to haemodialysis (HD) for FLC clearance. METHODS We retrospectively identified all renal replacement therapy (RRT) sessions perform...

Online haemodiafiltration (HDF) is increasingly used in clinical practice as a routine intermittent dialysis modality. It is well known that renal impairment and renal replacement therapy can substantially affect the pharmacokinetic behaviour of several drugs. However, surprisingly few data are available on the need for specific dose adjustments during HDF. Due to convection, drug clearance may...

BACKGROUND Patients with end-stage renal disease (ESRD) have increased fasting concentrations and disturbed postprandial responses of several glucoregulatory hormones. We aimed to evaluate the impact of high-flux haemodialysis (HD) and high-volume haemodiafiltration (HDF) on fasting and postprandial plasma levels of glucoregulatory pancreatic and gut peptide hormones in ESRD patients. METHODS...

Synchronous Dataflow (SDF) is useful in modeling communications and signal processing systems. We describe a communication actor library based on the SDF semantics in Ptolemy II and show how to use these actors to simulate communication systems. However, many communication and signal processing systems nowadays use adaptive algorithms and control protocols. These sometimes violate SDF principle...

BACKGROUND The autonomic nervous system plays a central role in the maintenance of hemodynamic stability. Cardiac autonomic dysfunction may result in serious complications, such as sudden cardiac death. Heart rate variability (HRV) is significantly reduced in patients undergoing chronic hemodialysis (HD). The aim of this study was to evaluate the effect of on-line hemodiafiltration (OL-HDF) on ...

BACKGROUND Convective dialysis strategies are superior in the removal of protein-bound uraemic retention solutes. Mid-dilution and mixed-dilution haemodiafiltration (HDF), both combining pre-dilution and post-dilution, are promising options to further improve removal capacity and have been shown of additional benefit for large middle molecules. In this study, we compared the removal of small wa...

Human diploid fibroblasts (HDF) immortalized by hTERT and simian virus 40 (SV40) early region (ER) exhibit a limited degree of transformation upon the expression of activated H-RAS (H-RAS V12) compared with rat embryonic fibroblasts (REF) immortalized by SV40 ER. Here, we identified FRA1 as a determinant for this difference in RAS-induced transformation. FRA1 was not induced by H-RAS V12 in the...

We report on sensitive radio observations made with the VLA at 8.5 GHz, centered on the Hubble Deep Field (HDF). We collected data in the A, CnB, C, DnC, and D configurations, corresponding to angular resolutions ranging from 0.3 to 10. We detected 29 radio sources in a complete sample within 4.6 of the HDF center and above a flux density limit of 9.0 μJy (5 σ). Seven of these sources are locat...

We calculate the expected number of multiply imaged galaxies in the Hubble Deep Field (HDF), using photometric redshift information for galaxies with that were detected in all four HDF passm I \ 27 bands. A comparison of these expectations with the observed number of strongly lensed galaxies places a lower limit on the current value of where is the cosmological mass density of the universe ) m ...