The nature of the substance with thyroid-stimulating activity (TSA) present in human chorionic gonadotropin (hCG) prepared from pregnancy urine was investigated. In the mouse thyrotropin bioassay, the characteristic maximum of blood radioactivity obtained with the TSA in hCG preparations occurred after that obtained with pituitary thyrotropin (hTSH) but before that obtained with long-acting thy...

Testosterone is produced in male rats by the action of luteinizing hormone (LH), an anterior pituitary hormone which interacts with receptors on Leydig cells (testes) to activate adenylate cyclase. A most frequently used agonist for LH is human chorionic gonadotropin (hCG), a hormone synthesized by the placenta during the early stages of pregnancy. Like LH, it is a heterodimer consisting of two...

OBJECTIVE To compare serum human chorionic gonadotropin (hCG) titers using 2 commercially available hCG immunoassays in patients with gestational trophoblastic neoplasia (GTN). STUDY DESIGN A total of 213 serum samples from 39 patients with uneventful moles and 697 serum samples from 17 patients with low-risk and high-risk GTN were obtained and subsequently measured with both the hCG C-termin...

The placenta may be involved in the regulation of the maternal thyroid function during pregnancy. As human chorionic gonadotropin (hCG) is a primary protein from the placenta, we examined the thyrotropic activity of hCG and its derivatives using tissue culture and monolayer cell culture of human thyroid glands. The TSH receptor preparation was made from thyroid tissues, and its binding affinity...

Trisomy 21 is associated with high maternal serum concentrations of intact human chorionic gonadotrophin alpha(HCG) and free beta-HCG whereas these concentrations are markedly decreased in trisomy 18. In this study, we investigated the effect of trisomy 21 and 18 on endogenous HCG concentrations and luteinizing hormone (LH)/HCG receptor expression in placental villous tissue in eight trisomy 21...

Human chorionic gonadotropin (hCG) is a glycoprotein hormone comprising 2 subunits, alpha and beta joined non covalently. While similar in structure to luteinizing hormone (LH), hCG exists in multiple hormonal and non-endocrine agents, rather than as a single molecule like LH and the other glycoprotein hormones. These are regular hCG, hyperglycosylated hCG and the free beta-subunit of hyperglyc...

Aim. To analyse the levels of serum beta-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein A (PAPP-A) in pregnant women without fetal chromosomal abnormalities with trisomy 21 (Down syndrome) or 18 (Edwards syndrome). Materials Methods. We performed a retrospective analysis biochemical parameters 1214 who had previously undergone karyotyping as part prenatal postnatal...

Vertical-cavity surface-emitting lasers (VCSELs) have been widely used in consumer electronics, light detection and ranging, optical interconnects, atomic sensors, so on. In this paper, a VCSEL with the surface metastructure like one-dimensional high-contrast grating (HCG), based on HCG-DBR vertical cavity, was first designed fabricated. The polarization characteristic of HCG-VCSEL were experim...

BACKGROUND hCG is a wonder. Firstly, because hCG is such an extreme molecule. hCG is the most acidic glycoprotein containing the highest proportion of sugars. Secondly, hCG exists in 5 common forms. Finally, it has so many functions ranging from control of human pregnancy to human cancer. This review examines these molecules in detail. CONTENT These 5 molecules, hCG, sulfated hCG, hyperglycos...

Aim Outside of Japan, recombinant-human chorionic gonadotropin (r-hCG) is widely used for the induction of final follicular maturation and early luteinization in women undergoing ovulation induction; whereas in Japan, urine-derived hCG (u-hCG) is predominantly used. The primary objective of this study was to demonstrate the non-inferiority of r-hCG to u-hCG for ovulation induction, as assessed ...