Innate immune system activation is associated with atherosclerotic lesion development. The specific sites of lesion development are believed to be defined by the shear stress of blood flow. Consequently, we investigated the responsiveness of human coronary artery endothelial cells (HCAECs) to Toll-like receptor (TLR) 2 and 4 agonists in an in vitro model of chronic laminar flow. HCAECs under ch...

Paclitaxel-eluting stents dramatically reduce rates of in-stent restenosis; however, paclitaxel is known to lead to endothelial dysfunction. Protective effects of nicorandil on paclitaxel-induced endothelial dysfunction by examining flow-mediated dilation (FMD) were investigated in anesthetized rats. After 7-day osmotic infusion of paclitaxel (5 mg/kg per day), FMD was measured by high-resoluti...

The expression of vascular adhesion molecule-1 (VCAM-1) by endothelial cells may play a major role in atherogenesis. The actual mechanisms of chlamydia pneumoniae (C. pneumoniae) relate to atherogenesis are unclear. We investigate the influence of VCAM-1 expression in the GroEL1 from C. pneumoniae-administered human coronary artery endothelial cells (HCAECs) and hypercholesterolemic rabbits. In...

Background: This study investigated the association between long non-coding RNAs (lncRNAs) and coronary heart disease (CHD) further elucidated potential biological roles of lncRNAs in CHD pathogenesis. Methods: A case-control (590 patients 590 controls) was conducted from February 2017 March 2019 Fuzhou, China. Environmental factors were using questionnaires physical examinations. Five represen...

Our study aimed to investigate the diagnostic value of long non-coding RNA (lncRNA) GAS5 for coronary artery disease (CAD) and to explore the mechanism of the role of GAS5 in CAD. A total of 30 patients with CAD were selected from January 2015 to January 2017 in The First Hospital of Tianmen. In addition, 30 healthy individuals were selected as a control group, and patients with various other t...

Our study aims to investigate the roles of microRNA-130a (miR-130a) in human coronary artery endothelial cells (HCAECs) injury and inflammatory responses by targeting PTEN through the PI3K/Akt/eNOS signaling pathway. HCAECs were treated with 1.0 mmol/L homocysteine (HCY) and assigned into eight groups: the blank group, the negative control (NC) group, the miR-130a mimics group, the miR-130a inh...

Submit Manuscript | http://medcraveonline.com Abbrevations: PBEF: Pre-B cell colony Enhancing Factor; NAD: Nicotinamide Adenine Dinucleotide; Sir2: Silent information regulator 2; NMN: Nicotinamide Mononucleotide; GLP-1: Glucagon Like Peptide-1; SAT: Subcutaneous Adipose Tissue; VAT: Visceral Adipose Tissue; FSIGT: Frequently Sampled Intravenous Glucose Tolerance; IMCL: Intramyocellular Lipid; ...

Oxidized low-density lipoprotein (ox-LDL) induces apoptosis in endothelial cells. However, steps leading to ox-LDL-induced apoptosis remain unclear. We examined the role of ox-LDL and its newly described receptor LOX-1 in the expression of intracellular pro- and antiapoptotic proteins and caspase pathways in human coronary artery endothelial cells (HCAECs). Cells were cultured and treated with ...

Bechara C, Wang X, Chai H, Lin PH, Yao Q, Chen C. Growthrelated oncogeneinduces endothelial dysfunction through oxidative stress and downregulation of eNOS in porcine coronary arteries. Am J Physiol Heart Circ Physiol 293: H3088–H3095, 2007. First published September 14, 2007; doi:10.1152/ajpheart.00473.2007.—Growth-related oncogene(GRO) is a member of the CXC chemokine family, which is involve...

Growth-related oncogene-alpha (GRO-alpha) is a member of the CXC chemokine family, which is involved in the inflammatory process including atherosclerosis. We hypothesized that GRO-alpha may affect endothelial functions in both porcine coronary arteries and human coronary artery endothelial cells (HCAECs). Vasomotor function was analyzed in response to thromboxane A2 analog U-46619 for contract...